Abstract
OBJECTIVE: To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology.
METHODS: This was a prospective multicenter study of 1714 women with biopsy-confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high-end ultrasound equipment. Clinical and sonographic data were entered into a web-based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the c-statistic.
RESULTS: In total, 1538 women were included in the final analysis. Median age was 65 (range, 27-98) years, median body mass index was 28.4 (range 16-67) kg/m2 , 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High-risk tumors, compared with low-risk tumors, were less likely to have regular endometrial-myometrial junction (difference of -23%; 95% CI, -27 to -18%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non-uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%).
CONCLUSION: Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high- and low-risk endometrial cancer. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 818-828 |
| Number of pages | 11 |
| Journal | Ultrasound in Obstetrics and Gynecology |
| Volume | 51 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2018 |
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Keywords
- Adult
- Aged
- Aged, 80 and over
- Consensus Development Conferences as Topic
- Cross-Sectional Studies
- Endometrial Neoplasms/classification
- Female
- Humans
- Middle Aged
- Neoplasm Grading
- Prospective Studies
- Reproducibility of Results
- Terminology as Topic
- Ultrasonography, Doppler, Color/standards
Cite this
Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature : prospective multicenter study. / Epstein, E; Fischerova, D; Valentin, L; Testa, A C; Franchi, D; Sladkevicius, P; Frühauf, F; Lindqvist, P G; Mascilini, F; Fruscio, R; Haak, L A; Opolskiene, G; Pascual, M A; Alcazar, J L; Chiappa, V; Guerriero, S; Carlson, J W; Van Holsbeke, C; Leone, F P G; De Moor, B; Bourne, T; van Calster, B; Installe, A; Timmerman, D; Verbakel, J Y; Van den Bosch, T.
In: Ultrasound in Obstetrics and Gynecology, Vol. 51, No. 6, 06.2018, p. 818-828.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature
T2 - prospective multicenter study
AU - Epstein, E
AU - Fischerova, D
AU - Valentin, L
AU - Testa, A C
AU - Franchi, D
AU - Sladkevicius, P
AU - Frühauf, F
AU - Lindqvist, P G
AU - Mascilini, F
AU - Fruscio, R
AU - Haak, L A
AU - Opolskiene, G
AU - Pascual, M A
AU - Alcazar, J L
AU - Chiappa, V
AU - Guerriero, S
AU - Carlson, J W
AU - Van Holsbeke, C
AU - Leone, F P G
AU - De Moor, B
AU - Bourne, T
AU - van Calster, B
AU - Installe, A
AU - Timmerman, D
AU - Verbakel, J Y
AU - Van den Bosch, T
N1 - Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
PY - 2018/6
Y1 - 2018/6
N2 - OBJECTIVE: To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology.METHODS: This was a prospective multicenter study of 1714 women with biopsy-confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high-end ultrasound equipment. Clinical and sonographic data were entered into a web-based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the c-statistic.RESULTS: In total, 1538 women were included in the final analysis. Median age was 65 (range, 27-98) years, median body mass index was 28.4 (range 16-67) kg/m2 , 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High-risk tumors, compared with low-risk tumors, were less likely to have regular endometrial-myometrial junction (difference of -23%; 95% CI, -27 to -18%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non-uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%).CONCLUSION: Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high- and low-risk endometrial cancer. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
AB - OBJECTIVE: To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology.METHODS: This was a prospective multicenter study of 1714 women with biopsy-confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high-end ultrasound equipment. Clinical and sonographic data were entered into a web-based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the c-statistic.RESULTS: In total, 1538 women were included in the final analysis. Median age was 65 (range, 27-98) years, median body mass index was 28.4 (range 16-67) kg/m2 , 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High-risk tumors, compared with low-risk tumors, were less likely to have regular endometrial-myometrial junction (difference of -23%; 95% CI, -27 to -18%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non-uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%).CONCLUSION: Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high- and low-risk endometrial cancer. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Consensus Development Conferences as Topic
KW - Cross-Sectional Studies
KW - Endometrial Neoplasms/classification
KW - Female
KW - Humans
KW - Middle Aged
KW - Neoplasm Grading
KW - Prospective Studies
KW - Reproducibility of Results
KW - Terminology as Topic
KW - Ultrasonography, Doppler, Color/standards
U2 - 10.1002/uog.18909
DO - 10.1002/uog.18909
M3 - Article
C2 - 28944985
VL - 51
SP - 818
EP - 828
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
SN - 0960-7692
IS - 6
ER -