@article{4617c8501c2e4139970f1f63dc13bd0c,
title = "Ultrasound dye-assisted parathyroidectomy (USDAP): Experience of a tertiary center: American Journal of Otolaryngology - Head and Neck Medicine and Surgery",
abstract = "Background: Primary hyperparathyroidism is primarily caused by parathyroid adenoma, followed by hyperplasia and parathyroid carcinoma. In the era of minimally invasive, targeted parathyroidectomy, the main challenge remains that of distinguishing intraoperatively pathological parathyroid from normal glands and peri-thyroid fat tissue. The aim of this study is to evaluate the surgical outcomes of a novel minimally invasive technique called ultrasound-guided dye-assisted parathyroidectomy (USDAP). Methods: We perform a retrospective analysis of patients affected by parathyroid adenoma, treated with USDAP at our institution between 2014 and 2019. Data were collected on patient age and sex, tumor location and size, preoperative investigations, histopathology, perioperative complications and surgical outcomes. Results: Between January 2014 and June 2019, 43 patients underwent parathyroidectomy in our Institute. Each case was discussed by the Institutional Multidisciplinary Board. All patients undergoing thyroidectomy together with USDAP or patients undergoing USDAP under endoscopic control were excluded from the present study. The final cohort, the largest to our knowledge, consisted of 29 patients. All patients were successfully treated with USDAP and remained disease-free during follow up. In all cases, pathological parathyroid was correctly identified and removed. There was no postoperative allergic reaction, nor were there neurotoxicity complications. USDAP permitted a shortening of operative and hospitalization time. Conclusions: USDAP is an effective and safe procedure both as first line treatment and as a re-operative procedure after previous surgical failures in selected cases. {\textcopyright} 2020 Elsevier Inc.",
keywords = "Dye, Parathyrodectomy, Ultrasound, USDAP, USDAS, anticoagulant agent, methoxy isobutyl isonitrile technetium tc 99m, methylene blue, adult, age, aged, anticoagulant therapy, Article, cancer diagnosis, cancer localization, cancer staging, cancer surgery, clinical article, cohort analysis, controlled study, female, follow up, histopathology, human, male, minimally invasive procedure, operation duration, parathyroid adenoma, parathyroidectomy, peroperative complication, peroperative echography, postoperative hemorrhage, preoperative evaluation, priority journal, retrospective study, sex difference, tertiary care center, thyroidectomy, tumor volume, ultrasound guided dye assisted parathyroidectomy, ultrasound surgery, adenoma, complication, computer assisted surgery, echography, hyperparathyroidism, length of stay, middle aged, minimally invasive surgery, parathyroid tumor, procedures, reoperation, treatment outcome, Adenoma, Adult, Aged, Female, Humans, Hyperparathyroidism, Length of Stay, Male, Middle Aged, Minimally Invasive Surgical Procedures, Operative Time, Parathyroid Neoplasms, Parathyroidectomy, Reoperation, Retrospective Studies, Surgery, Computer-Assisted, Treatment Outcome, Ultrasonography",
author = "F. Chu and G. Giugliano and M.S. Lazio and M. Proh and M. Tagliabue and {De Fiori}, E. and M.F. Manzoni and M. Ansarin",
note = "Export Date: 2 March 2021 CODEN: AJOTD Correspondence Address: Tagliabue, M.; Department of Otorhinolaryngology and Head and Neck Surgery, Via Ripamonti 435, Italy; email: marta.tagliabue@ieo.it Chemicals/CAS: methoxy isobutyl isonitrile technetium tc 99m, 109581-73-9; methylene blue, 61-73-4 References: Guilmette, J., Sadow, P.M., Parathyroid pathology (2019) Surg Pathol, 12, pp. 1007-1019. , 2019; Press, D.M., Siperstein, A.E., Berber, E., The prevalence of undiagnosed and unrecognized primary hyperparathyroidism: a population-based analysis from the electronic medical record (2013) Surgery, 154 (6), pp. 1232-1237. , Dec; Cope, O., Keynes, W.M., Roth, S.I., Castleman, B., Primary chief-cell hyperplasia of the parathyroid glands: a new entity in the surgery of hyperparathyroidism (1958) Ann Surg, 148, pp. 375-388; Molinari, A.S., Irvin, G.L., Deriso, G.T., Bott, L., Incidence of multiglandular disease in primary hyperparathyroidism determined by parathyroid hormone secretion (1996) Surgery, 120 (6), pp. 934-936; Bilezikian, J.P., Bandeira, L., Khan, A., Cusano, N.E., Hyperparathyroidism (2018) Lancet, 391 (10116), pp. 168-178. , Jan 13; Bilezikian, J.P., Brandi, M.L., Eastell, R., Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop (2014) J Clin Endocrinol Metab, 99, pp. 3561-3569; Yeung, M., (2020), Parathyroidectomy without the utilisation of iPTH: the gold standard is still a good operation—how understanding the anatomy and a simple US can help. World J Surg; Abbaci, M., De Leeuw, F., Breuskin, I., Parathyroid gland management using optical technologies during thyroidectomy or parathyroidectomy: a systematic review (2018) Oral Oncol, 87, pp. 186-196; Wolf, H.W., Grumbeck, B., Runkel, N., Intraoperative verification of parathyroid glands in primary and secondary hyperparathyroidism using near-infrared autofluorescence (IOPA) (2019) Updates Surg, 71 (3), pp. 579-585. , Sep; Norman, J., Politz, D., 5,000 parathyroid operations without frozen section or PTH assays: measuring individual parathyroid gland hormone production in real time (2009) Ann Surg Oncol, 16 (3), pp. 656-666; Giugliano, G., DE Fiori, E., Proh, M., Ultrasound dye-assisted surgery (USDAS): a promising diagnostic and therapeutic tool for the treatment of cancer recurrences in the neck (2011) Acta Otorhinolaryngol Ital, 31 (4), pp. 222-227. , Aug; Khan, A.A., Khatun, Y., Walker, A., Jimeno, J., Hubbard, J.G., Role of intraoperative PTH monitoring and surgical approach in primary hyperparathyroidism (2016) Ann Med Surg, 4, pp. 301-305; Butt, H.Z., Husainy, M., Bolia, A., Ultrasonography alone can reliably locate parathyroid tumours and facilitates minimally invasive parathyroidectomy (2015) Ann R Coll Surg Engl, 97, pp. 420-424; Schneider, R., Hinrichs, J., Meier, B., Walz, M.K., Alesina, P.F., Minimally invasive parathyroidectomy without intraoperative PTH performed after positive ultrasonography as the only diagnostic method in patients with primary hyperparathyroidism (2019) World J Surg, 43, pp. 1525-1531; Mazotas, I.G., Yen, T.W.F., Doffek, K., Persistent/recurrent primary hyperparathyroidism: does the number of abnormal glands play a role? (2020) J Surg Res, 246, pp. 335-341. , Feb. [Epub 2019 Oct 18]; Bandeira, F., Griz, L., Chaves, N., Diagnosis and management of primary hyperparathyroidism—a scientific statement from the Department of Bone Metabolism, the Brazilian Society for Endocrinology and Metabolism (2013) Arq Bras Endocrinol Metabol, 57, pp. 406-424; Coan, K.E., Yen, T.W.F., Carr, A.A., Evans, D.B., Wang, T.S., Confirmation of parathyroid tissue: are surgeons aware of new and novel techniques? (2019) J Surg Res, 246, pp. 139-144. , Sep 27; Garbutt, L., Sigvaldason, H., Sharaf Eldin, M.H., Dembinski, T., Nason, R.W., Pathak, K.A., What is the most appropriate intraoperative baseline parathormone? A prospective cohort study (2016) Int J Surg, 25, pp. 49-53. , Jan; Iwata, A.J., Wertz, A.S., Alluri, S., Singer, M.C., A faster parathyroidectomy: techniques to shorten non-surgical operating room time (2019) Am J Otolaryngol, 40 (6). , 102292. Nov - Dec; Laird, A.M., Libutti, S.K., Minimally invasive parathyroidectomy versus bilateral neck exploration for primary hyperparathyroidism (2016) Surg Oncol Clin N Am, 25 (1), pp. 103-118. , Jan; Tolley, N., Arora, A., Palazzo, F., Robotic-assisted parathyroidectomy: a feasibility study (2011) Otolaryngol Head Neck Surg, 144, pp. 859-866; Tolley, N., Garas, G., Palazzo, F., Long-term prospective evaluation comparing robotic parathyroidectomy with minimally invasive open parathyroidectomy for primary hyperparathyroidism (2016) Head Neck, 38, pp. E300-E306; Patel, H.P., Chadwick, D.R., Harrison, B.J., Balasubramanian, S.P., Systematic review of intravenous methylene blue in parathyroid surgery (2012) Br J Surg, 99 (10), pp. 1345-1351; Mihai, R., Mitchell, E.W., Warwick, J., Dose-response and postoperative confusion following methylene blue infusion during parathyroidectomy (2007) Can J Anaesth, 54, pp. 79-81; Harari, A., Sippel, R.S., Goldstein, R., Successful localization of recurrent thyroid cancer in reoperative neck surgery using ultrasoundguided methylene blue dye injection (2012) J Am Coll Surg, 215 (4), pp. 555-561. , Oct; Candell, L., Campbell, M.J., Shen, W.T., Ultrasound-guided methylene blue dye injection for parathyroid localization in the reoperative neck (2014) World J Surg, 38, pp. 88-91; Haciyanli, M., Koruyucu, M.B., Erdoğan, N.K., Successful localization of abnormal parathyroid gland using ultrasound-guided methylene blue dye injection in the reoperative neck (2015) Indian J Surg, 77, pp. S1094-S1097. , December; Carneiro-Pla, D., Contemporary and practical uses of intraoperative parathyroid hormone monitoring (2011) Endocr Pract, 17, pp. 44-53. , Mar-Apr; Grant, C.S., van Heerden, J.A., Charboneau, J.W., James, E.M., Reading, C.C., Clinical management of persistent and/or recurrent primary hyperparathyroidism (1986) World J Surg, 10 (4), pp. 555-565 12; Akerstr{\"o}m, G., Rudberg, C., Grimelius, L., Johansson, H., Lundstr{\"o}m, B., Rastad, J., Causes of failed primary exploration and technical aspects of reoperation in primary hyperparathyroidism (1992) World J Surg, 16 (4), pp. 565-568",
year = "2020",
doi = "10.1016/j.amjoto.2020.102558",
language = "English",
volume = "41",
journal = "Am. J. Otolaryngol. Head Neck Med. Surg.",
issn = "0196-0709",
publisher = "W.B. Saunders Ltd",
number = "6",
}