Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma: A feasibility study on three cases with pathological and immunohistochemical evaluation

Roberto Valcavi, Simonetta Piana, Giorgio Stecconi Bortolan, Roberta Lai, Verter Barbieri, Roberto Negro

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Ultrasound-guided thermal laser ablation (LA) is a nonsurgical technique that has been proposed, but not fully assessed, for papillary thyroid microcarcinoma (PTMC) treatment. The objectives of this study were to evaluate the clinical feasibility of LA on PTMC as a primary treatment and to prove histologically the absence of residual viable tumor after LA procedure. Methods: Three patients with a Thy 6 diagnosis at fine-needle aspiration cytology with a single PTMC smaller than 10 mm volunteered after full explanation of the protocol. At ultrasound examination, patients had no extrathyroid extension and no evidence of lymph node metastasis. Patients underwent percutaneous ultrasound-assisted LA of the PTMC in the operating room under general anesthesia. One 300 μm plane-cut optic fiber was inserted through the sheath of 21G Chiba needle, exposing 5 mm of the nude fiber in direct contact with tumor tissue, and connected with a laser source operating at 1.064 μm with 3 W output power. Total energy delivery was 1800 J. The surgeon directly started a standard total thyroidectomy. During surgical inspection, no remarkable laser sign was observed in the muscles, the perithyroidal tissues, or the recurrent laryngeal nerves. Results: Conventional histology showed destructured and carbonized tissue. Lack of vitality was demonstrated by complete loss of TTF1 and antimitochondria antibody expression in the whole ablated area and in the rim of normal tissue surrounding the tumor. BRAF V600E mutation was detected in cases 1 and 2. Furthermore, in cases 2 and 3, incidental papillary microfoci were found. A lymph node micrometastasis (200 μm) was observed in case 2. Conclusions: This study demonstrates that percutaneous LA is technically feasible for complete PTMC destruction. Now, LA may be useful in selected patients with PTMC, either when the surgeon or a patient refuses surgery, or when the patient is at high risk for an operation. LA may become a primary choice of treatment for PTMC only if future new knowledge would permit preoperative recognition of multifocality and lymph node metastasis.

Original languageEnglish
Pages (from-to)1578-1582
Number of pages5
JournalThyroid
Volume23
Issue number12
DOIs
Publication statusPublished - Dec 1 2013

Fingerprint

Feasibility Studies
Laser Therapy
Lymph Nodes
Lasers
Neoplasm Metastasis
Recurrent Laryngeal Nerve
Neoplasm Micrometastasis
Thyroidectomy
Residual Neoplasm
Operating Rooms
Fine Needle Biopsy
Papillary Thyroid Microcarcinoma
General Anesthesia
Needles
Cell Biology
Neoplasms
Histology
Therapeutics
Hot Temperature
Muscles

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma : A feasibility study on three cases with pathological and immunohistochemical evaluation. / Valcavi, Roberto; Piana, Simonetta; Bortolan, Giorgio Stecconi; Lai, Roberta; Barbieri, Verter; Negro, Roberto.

In: Thyroid, Vol. 23, No. 12, 01.12.2013, p. 1578-1582.

Research output: Contribution to journalArticle

Valcavi, Roberto ; Piana, Simonetta ; Bortolan, Giorgio Stecconi ; Lai, Roberta ; Barbieri, Verter ; Negro, Roberto. / Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma : A feasibility study on three cases with pathological and immunohistochemical evaluation. In: Thyroid. 2013 ; Vol. 23, No. 12. pp. 1578-1582.
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AU - Negro, Roberto

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