Ultrasound stimulus to enhance the bone regeneration capability of gelatin cryogels.

Lorenzo Fassina, Livia Visai, Giovanni Magenes, Jorg Schelfhout, Nora Bloise, Federica Riva, Claudia Omes, Maria Antonietta Avanzini, Maria Gabriella Cusella De Angelis, Francesco Benazzo, Manuel Dierick, Luc Van Hoorebeke, Peter Dubruel, Sandra Van Vlierberghe

Research output: Contribution to journalArticlepeer-review


In the present study, gelatin-based cryogels have been seeded with human SAOS-2 osteoblasts. In order to overcome the drawbacks associated with in vitro culture systems, such as limited diffusion and inhomogeneous cell-matrix distribution, this work describes the application of ultrasounds (average power, 149 mW; frequency, 1.5 MHz) to physically enhance the cell culture in vitro. The results indicate that the physical stimulation of cell-seeded gelatin-based cryogels upregulates the bone matrix production.

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics


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