Results of studies carried out on the effects of antilymphocyte serum (ALS) administration observed in the thymus during the last two years are reported. Evidence is presented in favour of the concept that recovery from some ALS effects is thymus dependent. For the study of ultrastructural and functional effects of the thymus in ALS treated animals, both intact and adrenalectomized mice were used in order to be able to distinguish between direct effects and those mediated by the secretion of corticosteroids. In intact mice serum administration caused heavy damage of dark reticular epithelial cells (DREC) and thymocytes. In adrenalectomized mice the degree of damage of the thymus was lower, and it was largely DREC that were altered. Functional effects on the thymus of ALS administration were studied in thymectomized mice in experiments in which thymuses from ALS pretreated animals were implanted intraperitoneally. By variation of the length of time following ALS pretreatment, the recovery inducing capacity of implanted thymuses in thymectomized mice was evaluated. Complete similarity between functional and ultrastructural data was found. In particular, it was possible to observe that thymuses from ALS pretreated mice with clearcut damage of DREC could not induce recovery from some ALS effects after implantation. The best recovery inducing capacity was shown by thymuses collected from ALS pretreated adrenalectomized mice.
|Translated title of the contribution||Ultrastructural and functional effects on the mouse thymus induced by antilymphocytic serum|
|Number of pages||18|
|Journal||Giornale di Batteriologia Virologia ed Immunologia|
|Publication status||Published - 1974|
ASJC Scopus subject areas
- Immunology and Microbiology(all)