Ultrastructural localization of anionic phospholipids in skeletal muscle plasma membrane

M. Moggio, E. Bonilla

Research output: Contribution to journalArticlepeer-review

Abstract

Polymyxin B was used as a probe to label anionic phospholipids in skeletal muscle plasma membrane. This antibiotic produces muscle surface membrane lesions that can be identified in both thin sections and freeze-fracture replicas. The membrane perturbations assumed a patchy distribution with a preferential localization at the level of the I band and A-I bands junction. Intramembraneous particles were also observed within the lesions. We consider the possibility that microdomains of anionic phospholipids in muscle plasma membrane may function in the binding of Ca++.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalHistochemistry
Volume83
Issue number6
DOIs
Publication statusPublished - Nov 1985

ASJC Scopus subject areas

  • Anatomy

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