Ultrastructure of endocrine cells and argyrophil carcinoids of the stomach of Praomys (Mastomys) natalensis

C. Capella, E. Solcia, K. C. Snell

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Abstract

Endocrine cells of the gastric mucosa and gastric argyrophil carcinoids of Praomys (Mastomys) natalensis were compared. Based on their ultrastructural and staining patterns, 5 types of endocrine cells were identified in nontumorous gastric mucosa: the 5 hydroxytryptamine (5HT) storing argentaffin or enterochromaffin (EC) cell, primarily of the pyloric mucosa; the gastrin (G) cell, restricted to the pyloric glands; the D cell, resembling D cells of the pancreatic islets and found in both pyloric and oxyntic mucosa; and 2 types of argyrophil cells peculiar to the oxyntic glands, the ECL cell and a round granule 'A' cell differing ultrastructurally from glucagon producing A cell of Mastomys' pancreas. The anaplastic cells of Mastomys' carcinoids partially reproduced the ultrastructural and staining patterns of ECL and round granule cells, to which they could be genetically related. EC, G, and D cells seemed unrelated to tumor cells. In tumor bearing animals, EC and mucous cells showed signs of functional stimulation, whereas G cells seemed dormant; these findings may be related to the histamine dependent hyperchlorhydria of such animals.

Original languageEnglish
Pages (from-to)1471-1485
Number of pages15
JournalJournal of the National Cancer Institute
Volume50
Issue number6
Publication statusPublished - 1973

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Murinae
Endocrine Cells
Carcinoid Tumor
Enterochromaffin Cells
Stomach
Gastrin-Secreting Cells
Somatostatin-Secreting Cells
Gastric Mucosa
Mucous Membrane
Enterochromaffin-like Cells
Staining and Labeling
Glucagon
Islets of Langerhans
Histamine
Pancreas
Neoplasms
Serotonin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Ultrastructure of endocrine cells and argyrophil carcinoids of the stomach of Praomys (Mastomys) natalensis. / Capella, C.; Solcia, E.; Snell, K. C.

In: Journal of the National Cancer Institute, Vol. 50, No. 6, 1973, p. 1471-1485.

Research output: Contribution to journalArticle

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