Ultrastructure of internal jugular vein defective valves

P. Zamboni, V. Tisato, E. Menegatti, F. Mascoli, S. Gianesini, F. Salvi, P. Secchiero

Research output: Contribution to journalArticle

Abstract

Objectives To study the ultrastructure of intraluminal defects found in the internal jugular vein by using a scanning electron microscopy. Methods Using a scanning electron microscopy, intraluminal septa and/or defective valves blocking the flow in the distal internal jugular vein of seven patients were studied together with the adjacent wall and compared with control specimen. Results The internal jugular veins’ wall showed a significant derangement of the endothelial layer as compared to controls. Surprisingly, no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina. Conclusions Although the lack of endothelial cells in the internal jugular vein intraluminal obstacles is a further abnormality found in course of chronic cerebrospinal venous insufficiency, our investigation cannot clarify whether this finding is primary or caused by progressive loss of endothelium in relation to altered haemodynamic forces and/or to a past post-thrombotic/inflammatory remodelling.

Original languageEnglish
Pages (from-to)644-647
Number of pages4
JournalPhlebology
Volume30
Issue number9
DOIs
Publication statusPublished - Oct 19 2015

Fingerprint

Jugular Veins
Electron Scanning Microscopy
Endothelial Cells
Venous Insufficiency
Endothelium
Hemodynamics

Keywords

  • CCSVI
  • endothelial cell
  • internal jugular vein
  • intraluminal defects
  • scanning electron microscopy
  • truncular venous malformation
  • ultrastructure
  • Venous valves

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Zamboni, P., Tisato, V., Menegatti, E., Mascoli, F., Gianesini, S., Salvi, F., & Secchiero, P. (2015). Ultrastructure of internal jugular vein defective valves. Phlebology, 30(9), 644-647. https://doi.org/10.1177/0268355514541980

Ultrastructure of internal jugular vein defective valves. / Zamboni, P.; Tisato, V.; Menegatti, E.; Mascoli, F.; Gianesini, S.; Salvi, F.; Secchiero, P.

In: Phlebology, Vol. 30, No. 9, 19.10.2015, p. 644-647.

Research output: Contribution to journalArticle

Zamboni, P, Tisato, V, Menegatti, E, Mascoli, F, Gianesini, S, Salvi, F & Secchiero, P 2015, 'Ultrastructure of internal jugular vein defective valves', Phlebology, vol. 30, no. 9, pp. 644-647. https://doi.org/10.1177/0268355514541980
Zamboni P, Tisato V, Menegatti E, Mascoli F, Gianesini S, Salvi F et al. Ultrastructure of internal jugular vein defective valves. Phlebology. 2015 Oct 19;30(9):644-647. https://doi.org/10.1177/0268355514541980
Zamboni, P. ; Tisato, V. ; Menegatti, E. ; Mascoli, F. ; Gianesini, S. ; Salvi, F. ; Secchiero, P. / Ultrastructure of internal jugular vein defective valves. In: Phlebology. 2015 ; Vol. 30, No. 9. pp. 644-647.
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