Ultraviolet irradiation and cytokines as regulators of HIV latency and expression

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of the human immunodeficiency virus (HIV) to persist and replicate in human CD4+ T lymphocytes and mononuclear phagocytes is under the control of both virally encoded proteins and a variety of host-related factors. Ultraviolet (UV) light has been shown to induce transcription and expression of HIV. Both DNA damage and repair and DNA damage/repair-independent pathways caused by UV irradiation lead to expression of proviral HIV genomes via activation of the cellular transcription factor NF-κB. Transgenic mice that contain either long terminal repeat (LTR)-reporter genes or HIV genomes, either full length or deleted in the gag-pol region, express RNA and proteins at the epidermal level, particularly after UV irradiation. Furthermore, UV-triggered release of soluble factors capable of inducing expression of HIV in non-irradiated cells has been observed. Among other host factors, the functional network of pro-inflammatory and immunoregulatory cytokines has been demonstrated to act as a potent regulator of HIV replication, at least in different in vitro systems of infection.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalChemico-Biological Interactions
Volume91
Issue number2-3
DOIs
Publication statusPublished - 1994

Keywords

  • Cytokines
  • HIV
  • Latency
  • LTR
  • NF-κB
  • Ultraviolet light

ASJC Scopus subject areas

  • Toxicology

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