Umbilical cord blood transplant from HLA-mismatched unrelated donor in high-risk leukemia

W. Arcese, A. P. Iori, M. Screnci, C. Guglielmi, A. Mengarelli, D. Carmini, A. M. Testi, M. L. Moleti, G. Cimino, P. Perrone, L. Laurenti, L. Elia, F. Boecklin, A. Romano, L. De Felice, F. Mandelli

Research output: Contribution to journalArticlepeer-review

Abstract

Twelve consecutive children with high-risk leukemia have been submitted to UCB transplant from unrelated 1 or 2 loci HLA-mismatched donor. All patients received an identical regimen for conditioning and GVHD prophylaxis. The median dose of viable nucleated cells infused was 2.8 x 107/kg bw (range 1.4-7.9). Of 11 patients evaluable for engraftment, the hematopoiesis was of full donor origin in seven patients and autologous in four. The probability of disease-free survival at 1 and 2 years from UCB transplant is 60 and 42%, respectively.

Original languageEnglish
JournalBone Marrow Transplantation
Volume21
Issue numberSUPPL. 3
Publication statusPublished - 1998

Keywords

  • Cord blood transplant
  • Engraftment
  • Unrelated mismatched transplant

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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