Umbilical cord blood transplants

Eliane Gluckman, Franco Locatelli

Research output: Contribution to journalArticle

Abstract

With the establishment of cord blood banks, the number of related and unrelated umbilical cord blood transplants is increasing worldwide. Close links have been established with the cord blood banks. Available data showed that umbilical cord blood transplants offer overall results comparable to those obtained with related or unrelated bone marrow transplants. Several differences were found: engraftment with cord blood was delayed, resulting in an increased incidence of early transplant complications, and the incidence of acute and chronic graft-versus-host disease was significantly reduced with cord blood grafts, even in HLA-mismatched transplants and in adults. In patients with leukemia, the rate of relapse appeared to be similar to that documented in bone marrow transplant recipients. These data confirm the potential benefit of using umbilical cord blood hematopoietic stem cells for allogeneic transplants. (C) 2000 Lippincott Williams and Wilkins, Inc.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalCurrent Opinion in Hematology
Volume7
Issue number6
DOIs
Publication statusPublished - 2000

Fingerprint

Fetal Blood
Transplants
Blood Banks
Bone Marrow
Incidence
Graft vs Host Disease
Hematopoietic Stem Cells
Leukemia
Recurrence

ASJC Scopus subject areas

  • Hematology

Cite this

Umbilical cord blood transplants. / Gluckman, Eliane; Locatelli, Franco.

In: Current Opinion in Hematology, Vol. 7, No. 6, 2000, p. 353-357.

Research output: Contribution to journalArticle

Gluckman, Eliane ; Locatelli, Franco. / Umbilical cord blood transplants. In: Current Opinion in Hematology. 2000 ; Vol. 7, No. 6. pp. 353-357.
@article{171c44ecce6b4ec2874a7d8b6755c3c7,
title = "Umbilical cord blood transplants",
abstract = "With the establishment of cord blood banks, the number of related and unrelated umbilical cord blood transplants is increasing worldwide. Close links have been established with the cord blood banks. Available data showed that umbilical cord blood transplants offer overall results comparable to those obtained with related or unrelated bone marrow transplants. Several differences were found: engraftment with cord blood was delayed, resulting in an increased incidence of early transplant complications, and the incidence of acute and chronic graft-versus-host disease was significantly reduced with cord blood grafts, even in HLA-mismatched transplants and in adults. In patients with leukemia, the rate of relapse appeared to be similar to that documented in bone marrow transplant recipients. These data confirm the potential benefit of using umbilical cord blood hematopoietic stem cells for allogeneic transplants. (C) 2000 Lippincott Williams and Wilkins, Inc.",
author = "Eliane Gluckman and Franco Locatelli",
year = "2000",
doi = "10.1097/00062752-200011000-00006",
language = "English",
volume = "7",
pages = "353--357",
journal = "Current Opinion in Hematology",
issn = "1065-6251",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Umbilical cord blood transplants

AU - Gluckman, Eliane

AU - Locatelli, Franco

PY - 2000

Y1 - 2000

N2 - With the establishment of cord blood banks, the number of related and unrelated umbilical cord blood transplants is increasing worldwide. Close links have been established with the cord blood banks. Available data showed that umbilical cord blood transplants offer overall results comparable to those obtained with related or unrelated bone marrow transplants. Several differences were found: engraftment with cord blood was delayed, resulting in an increased incidence of early transplant complications, and the incidence of acute and chronic graft-versus-host disease was significantly reduced with cord blood grafts, even in HLA-mismatched transplants and in adults. In patients with leukemia, the rate of relapse appeared to be similar to that documented in bone marrow transplant recipients. These data confirm the potential benefit of using umbilical cord blood hematopoietic stem cells for allogeneic transplants. (C) 2000 Lippincott Williams and Wilkins, Inc.

AB - With the establishment of cord blood banks, the number of related and unrelated umbilical cord blood transplants is increasing worldwide. Close links have been established with the cord blood banks. Available data showed that umbilical cord blood transplants offer overall results comparable to those obtained with related or unrelated bone marrow transplants. Several differences were found: engraftment with cord blood was delayed, resulting in an increased incidence of early transplant complications, and the incidence of acute and chronic graft-versus-host disease was significantly reduced with cord blood grafts, even in HLA-mismatched transplants and in adults. In patients with leukemia, the rate of relapse appeared to be similar to that documented in bone marrow transplant recipients. These data confirm the potential benefit of using umbilical cord blood hematopoietic stem cells for allogeneic transplants. (C) 2000 Lippincott Williams and Wilkins, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0033788193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033788193&partnerID=8YFLogxK

U2 - 10.1097/00062752-200011000-00006

DO - 10.1097/00062752-200011000-00006

M3 - Article

C2 - 11055508

AN - SCOPUS:0033788193

VL - 7

SP - 353

EP - 357

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

SN - 1065-6251

IS - 6

ER -