Umbilical cord blood (UCB) transplant from unrelated mismatched donor in patients with high risk (HR) leukemia

A. P. Iori, M. Screnci, C. Guglielmi, A. Mengarelli, D. Carmini, A. M. Testi, M. L. Moleti, G. Cimino, P. Perrone, L. Laurenti, L. Elia, F. Boecklin, A. Romano, F. Vulcano, L. De Felice, W. Arcese

Research output: Contribution to journalArticle

Abstract

Ten consecutive children with high risk leukemia have been submitted to UCB transplant from unrelated HLA mismatched donors. All patients received an identical regimen for conditioning and GVND prophylaxis. The median dose of viable nucleated cells infused was 2.6 x 106/kg b.w. Among the nine patients evaluable for engraftment the hematopoiesis was of full donor origin in six patients and autogolous in three. At a median follow-up of 9 months, six of nine (67%) patients are alive in CR.

Original languageEnglish
JournalBone Marrow Transplantation
Volume22
Issue numberSUPPL. 1
Publication statusPublished - 1998

Keywords

  • Cord blood transplant
  • Engraftment
  • Unrelated mismatched transplant

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Iori, A. P., Screnci, M., Guglielmi, C., Mengarelli, A., Carmini, D., Testi, A. M., Moleti, M. L., Cimino, G., Perrone, P., Laurenti, L., Elia, L., Boecklin, F., Romano, A., Vulcano, F., De Felice, L., & Arcese, W. (1998). Umbilical cord blood (UCB) transplant from unrelated mismatched donor in patients with high risk (HR) leukemia. Bone Marrow Transplantation, 22(SUPPL. 1).