UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen

P. Tassone, H. Bond, P. Bonelli, F. Tuccillo, L. Cecco, A. Lamberti, F. De Lorenzo, M. Cerra, M. C. Turco, S. Venuta

Research output: Contribution to journalArticle

Abstract

A monoclonal antibody (MoAb), UN-1, specific for a human thymocyte cell surface antigen was produced. The same MoAb recognized in immunofluorescence also cells of the human T line HPB-ALL, while did not bind human peripheral blood cells and cells of some T, B and myeloid lines. Western blotting analysis of thymocyte membranes with MoAb UN-1 revealed a structure with a molecular weight of 150 kDa. Therefore both the pattern of expression and the size of the antigen recognized by MoAb UN-1 did not correspond to any previously described cell surface molecule.

Original languageEnglish
Pages (from-to)128-129
Number of pages2
JournalPharmacological Research
Volume26
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 1992

Keywords

  • human thymocytes
  • monoclonal antibody

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Tassone, P., Bond, H., Bonelli, P., Tuccillo, F., Cecco, L., Lamberti, A., De Lorenzo, F., Cerra, M., Turco, M. C., & Venuta, S. (1992). UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen. Pharmacological Research, 26(SUPPL. 2), 128-129. https://doi.org/10.1016/1043-6618(92)90630-T