Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss

Pasquale Capaccio, Lorenzo Pignataro, Lorenzo M. Gaini, Paolo E. Sigismund, Cristina Novembrino, Rachele De Giuseppe, Valentina Uva, Armando Tripodi, Fabrizia Bamonti

Research output: Contribution to journalArticlepeer-review


An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalEuropean Archives of Oto-Rhino-Laryngology
Issue number2
Publication statusPublished - Feb 2012


  • Oxidative stress
  • Reactive oxygen species
  • Sudden sensorineural hearing loss
  • Total antioxidant capacity

ASJC Scopus subject areas

  • Otorhinolaryngology


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