Abstract
An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 449-453 |
| Number of pages | 5 |
| Journal | European Archives of Oto-Rhino-Laryngology |
| Volume | 269 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- Oxidative stress
- Reactive oxygen species
- Sudden sensorineural hearing loss
- Total antioxidant capacity
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss. / Capaccio, Pasquale; Pignataro, Lorenzo; Gaini, Lorenzo M.; Sigismund, Paolo E.; Novembrino, Cristina; De Giuseppe, Rachele; Uva, Valentina; Tripodi, Armando; Bamonti, Fabrizia.
In: European Archives of Oto-Rhino-Laryngology, Vol. 269, No. 2, 02.2012, p. 449-453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss
AU - Capaccio, Pasquale
AU - Pignataro, Lorenzo
AU - Gaini, Lorenzo M.
AU - Sigismund, Paolo E.
AU - Novembrino, Cristina
AU - De Giuseppe, Rachele
AU - Uva, Valentina
AU - Tripodi, Armando
AU - Bamonti, Fabrizia
PY - 2012/2
Y1 - 2012/2
N2 - An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.
AB - An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.
KW - Oxidative stress
KW - Reactive oxygen species
KW - Sudden sensorineural hearing loss
KW - Total antioxidant capacity
UR - http://www.scopus.com/inward/record.url?scp=84857048236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857048236&partnerID=8YFLogxK
U2 - 10.1007/s00405-011-1671-2
DO - 10.1007/s00405-011-1671-2
M3 - Article
VL - 269
SP - 449
EP - 453
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 2
ER -