Uncemented primary total hip arthroplasty, presentation of pain, and expression of osteonectin

Alina Beraudi, Monica Montesi, Francesco Traina, Stefano Falcioni, Susanna Stea, Aldo Toni

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Osteonectin (ON) is an important matrix glycoprotein highly expressed in bone. In several in vitro and animal model studies, ON was used as indicator of the state of osseointegration of implanted devices. There are, however, no studies on ON expression in the synovial fluid of patients with total hip joint replacement (THJR). The purpose of our study was to determine the ON concentration in synovial fluid from three groups of patients: primary uncemented THJR with hip pain ("pain" group; n=15) and without pain ("no-pain" group; n=12), and patients with osteoarthitis scheduled to receive a primary THJR (control group; n=5). For the prosthesized groups, the statistical nature of the correlation between ON concentration and patient age, in situ life of the THJR, presence of periprosthetic osteolysis, and presence of debris in the synovial fluid was individually investigated. ON concentration was determined using enzyme-linked immunosorbent assay, the presence of periprosthetic osteolysis was established using X-radiography and Engh's criteria, and the presence of debris was determined using digestion and EDX spectroscopy. ON concentration was significantly lower in the "pain" group compared with the "no-pain" one (median values 19.0 and 53.2ng/mL, respectively). ON concentration in the control group (median value: 16.9ng/mL) was comparable with that reported in the literature. In the prosthesized groups, ON concentration was not correlated with patient age, in situ life of the prosthesis, presence of periprosthetic osteolysis, or presence of debris in the synovial fluid. Our results suggest that cases of unexplained pain in THJR patients could be treated by paying special attention to the osseointegration status of the implant by using ON concentration as an early indicator of this status.

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalArtificial Organs
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Osteonectin
Arthroplasty
Hip
Replacement Arthroplasties
Debris
Pain
Fluids
Hip Replacement Arthroplasties
Hip Joint
Synovial Fluid
Osteolysis
Glycoproteins
Radiography
Osseointegration
Energy dispersive spectroscopy
Assays
Bone
Animals
Enzymes
Spectroscopy

Keywords

  • Hip prosthesis
  • Osteonectin
  • Pain
  • Synovial fluid
  • Total hip arthroplasty

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Uncemented primary total hip arthroplasty, presentation of pain, and expression of osteonectin. / Beraudi, Alina; Montesi, Monica; Traina, Francesco; Falcioni, Stefano; Stea, Susanna; Toni, Aldo.

In: Artificial Organs, Vol. 37, No. 6, 06.2013, p. 561-566.

Research output: Contribution to journalArticle

Beraudi, Alina ; Montesi, Monica ; Traina, Francesco ; Falcioni, Stefano ; Stea, Susanna ; Toni, Aldo. / Uncemented primary total hip arthroplasty, presentation of pain, and expression of osteonectin. In: Artificial Organs. 2013 ; Vol. 37, No. 6. pp. 561-566.
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