Uncertainty of fast biological radiation dose assessment for emergency response scenarios

Elizabeth A. Ainsbury, Manuel Higueras, Pedro Puig, Jochen Einbeck, Daniel Samaga, Joan Francesc Barquinero, Lleonard Barrios, Beata Brzozowska, Paola Fattibene, Eric Gregoire, Alicja Jaworska, David Lloyd, Ursula Oestreicher, Horst Romm, Kai Rothkamm, Laurence Roy, Sylwester Sommer, Georgia Terzoudi, Hubert Thierens, Francois TrompierAnne Vral, Clemens Woda

Research output: Contribution to journalArticlepeer-review


Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response. Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using simulated and real data from recent exercises. Results: The results demonstrate that a Bayesian method of uncertainty assessment is the most appropriate, even in the absence of detailed prior information. The relative accuracy and relevance of techniques for calculating uncertainty and combining assay results to produce single dose and uncertainty estimates is further discussed. Conclusions: Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.

Original languageEnglish
Pages (from-to)127-135
Number of pages9
JournalInternational Journal of Radiation Biology
Issue number1
Publication statusPublished - Jan 2 2017


  • Biodosimetry
  • radiation
  • retrospective dosimetry
  • triage screening
  • uncertainty

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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