Unchanged thyrotropin and prolactin responses to thyrotropin releasing hormone after indomethacin treatment

Paola Masturzo, T. Barreca, A. Gallamini, R. Gianrossi, G. Murialdo, M. C. Nizzo

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental effects of prostaglandin synthetase inhibitors have been considered in the literature as a clue to the possible interactions of prostaglandins with the hypothalamic releasing hormones at the pituitary level. Some results of the administration to man of these drugs are apparently in contrast with the in vivo and in vitro animal data. The present investigation deals with the comparison between the thyrotropin releasing hormone (TRH) effect on prolactin and thyrotropin when the hormone was administered intravenously at doses of 50, 100 and 200 μg respectively to three groups of six men (aged 22 to 30 years), before and on the sixth day of indomethacin administration (50 mg orally at 6-hour intervals). No significant change in the releasing hormone effect was observed either in the case of prolactin, where TRH caused a consistently similar release of the hormone at every dose employed, or in the case of thyrotropin, where a dose-dependent releasing effect was obtained before and after indomethacin treatment.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalJournal of Endocrinological Investigation
Volume1
Issue number2
DOIs
Publication statusPublished - 1978

Keywords

  • indomethacin
  • Prolactin
  • prostaglandins
  • thyrotropin
  • thyrotropin releasing hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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