Uncommon primary headaches

Giorgio Sandrini, Cristina Tassorelli, Natascia Ghiotto, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review


Purpose of review: The new International Classification of Headache Disorders was recently published by the International Headache Society. Several uncommon primary headaches, including some new clinical entities (e.g. hypnic headache), were included in the section on 'Cluster headache and other trigeminal autonomic neuralgias' and 'Other primary headaches'. The recent classification offers an interesting opportunity to evaluate the clinical role and to discuss the mechanisms of some of the more relevant uncommon primary headaches. Recent findings: Due to the low incidence of these uncommon headache forms, their diagnostic criteria, pathogenetic mechanisms and therapy are still debated. Differential diagnosis versus secondary headaches is also a crucial issue. In this review, some of the most important uncommon primary headaches are discussed in light of the most recent contributions to the literature. Summary: The review focuses on the update of the main uncommon primary headaches, intending to clarify some controversial points and to indicate some headlines for further research.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalCurrent Opinion in Neurology
Issue number3
Publication statusPublished - Jun 2006


  • Differential diagnosis
  • Pathogenesis
  • Trigeminal autonomic neuralgias
  • Uncommon primary headache

ASJC Scopus subject areas

  • Neuroscience(all)


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