Uncommon site of metastasis and prolonged survival in patients with anaplastic thyroid carcinoma: A systematic review of the literature

Aurora Mirabile, Matteo Biafora, Leone Giordano, Gianluigi Arrigoni, Maria Giulia Cangi, Italo Dell’oca, Francesca Lira Luce, Davide Di Santo, Andrea Galli, Michele Tulli, Renata Mellone, Davide Valsecchi, Vanesa Gregorc, Mario Bussi

Research output: Contribution to journalReview articlepeer-review

Abstract

Anaplastic thyroid carcinoma (ATC) is a very rare, highly aggressive malignant thyroid tumor with an overall survival from 3 to 5 months in most of the cases. Even the modern and intensive treatments seem not to be enough to provide a cure, also for the resectable ones, and the role of chemotherapy is still unclear but does not seem to prolong survival. Nevertheless, some patients survive longer and have a better outcome, even in the presence of metastasis, than what the literature reports. We present the case of a 64-year-old female affected by ATC, treated on February 2018 with surgery followed by chemoradiation. One year after surgery, the patient developed a subcutaneous recurrence that was radically resected and is still alive 29 months after the diagnosis. We propose a systematic review of the literature to deepen the knowledge of the prognostic factors of ATC with the aim to recognize and select the patients with a better outcome, even if metastatic, and to describe a very uncommon site of metastatization.

Original languageEnglish
Article number2585
Pages (from-to)1-14
Number of pages14
JournalCancers
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Anaplastic thyroid carcinoma
  • Case report
  • Infrequent metastatic sites
  • Long survival
  • Subcutaneous metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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