Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations

Maya R. Vilà, Josep Gámez, Abelardo Solano, Ana Playán, Simó Schwartz, Filippo M. Santorelli, Carles Cervera, Carlo Casali, Julio Montoya, Francesc Villarroya

Research output: Contribution to journalArticle

Abstract

Multiple symmetric lipomatosis (MSL) is a rare disorder characterised by large subcutaneous fat masses in some parts of the trunk. Mitochondrial disfunction is common in MSL, but the identity of the adipose cells developing in multiple lipomas is not well known. We determined that brown adipose tissue-specific uncoupling protein-1 (UCP-1) mRNA is expressed in the lipoma of a multiple symmetric lipomatosis patient bearing the 8344 mutation in the tRNALys gene of mitochondrial DNA. UCP1 mRNA was not detected in normal subcutaneous fat from the same patient or in the lipoma of another patient bearing a different mutation in the same tRNALys gene. These findings implicate brown adipose cells as the origin of lipomas in a subset of patients bearing tRNALys mutations in mitochondrial DNA. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)800-802
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number3
DOIs
Publication statusPublished - Nov 30 2000

Keywords

  • Brown adipose tissue
  • Mitochondria
  • Mitochondrial DNA
  • Multiple symmetric lipomatosis
  • Uncoupling protein-1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Vilà, M. R., Gámez, J., Solano, A., Playán, A., Schwartz, S., Santorelli, F. M., Cervera, C., Casali, C., Montoya, J., & Villarroya, F. (2000). Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations. Biochemical and Biophysical Research Communications, 278(3), 800-802. https://doi.org/10.1006/bbrc.2000.3828