TY - JOUR
T1 - Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations
AU - Vilà, Maya R.
AU - Gámez, Josep
AU - Solano, Abelardo
AU - Playán, Ana
AU - Schwartz, Simó
AU - Santorelli, Filippo M.
AU - Cervera, Carles
AU - Casali, Carlo
AU - Montoya, Julio
AU - Villarroya, Francesc
PY - 2000/11/30
Y1 - 2000/11/30
N2 - Multiple symmetric lipomatosis (MSL) is a rare disorder characterised by large subcutaneous fat masses in some parts of the trunk. Mitochondrial disfunction is common in MSL, but the identity of the adipose cells developing in multiple lipomas is not well known. We determined that brown adipose tissue-specific uncoupling protein-1 (UCP-1) mRNA is expressed in the lipoma of a multiple symmetric lipomatosis patient bearing the 8344 mutation in the tRNALys gene of mitochondrial DNA. UCP1 mRNA was not detected in normal subcutaneous fat from the same patient or in the lipoma of another patient bearing a different mutation in the same tRNALys gene. These findings implicate brown adipose cells as the origin of lipomas in a subset of patients bearing tRNALys mutations in mitochondrial DNA. (C) 2000 Academic Press.
AB - Multiple symmetric lipomatosis (MSL) is a rare disorder characterised by large subcutaneous fat masses in some parts of the trunk. Mitochondrial disfunction is common in MSL, but the identity of the adipose cells developing in multiple lipomas is not well known. We determined that brown adipose tissue-specific uncoupling protein-1 (UCP-1) mRNA is expressed in the lipoma of a multiple symmetric lipomatosis patient bearing the 8344 mutation in the tRNALys gene of mitochondrial DNA. UCP1 mRNA was not detected in normal subcutaneous fat from the same patient or in the lipoma of another patient bearing a different mutation in the same tRNALys gene. These findings implicate brown adipose cells as the origin of lipomas in a subset of patients bearing tRNALys mutations in mitochondrial DNA. (C) 2000 Academic Press.
KW - Brown adipose tissue
KW - Mitochondria
KW - Mitochondrial DNA
KW - Multiple symmetric lipomatosis
KW - Uncoupling protein-1
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U2 - 10.1006/bbrc.2000.3828
DO - 10.1006/bbrc.2000.3828
M3 - Article
C2 - 11095987
AN - SCOPUS:0034736071
VL - 278
SP - 800
EP - 802
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -