Uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging

Stefano Indraccolo, Stefan Walenta, Wolfgang Mueller-Klieser

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Induced metabolic bioluminescence imaging (imBI) is an imaging technique which enables detection of various metabolites associated with glycolysis in tumor sections. Signals captured by imBI can be used to chart the topographic distribution of lactate, glucose, pyruvate, and ATP and quantify their absolute amount. ImBi can enable us to perform metabolic classification of tumors as well as to detect metabolic changes in the glycolytic pathway associated with certain therapies, such as anti-angiogenic drugs.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages175-184
Number of pages10
Volume1464
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1464
ISSN (Print)10643745

Keywords

  • Angiogenesis
  • Bioluminescence
  • Glycolysis
  • Imaging
  • Tumor xenografts

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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