Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals

Franca Rosa Guerini, Sergio Lo Caputo, Andrea Gori, Alessandra Bandera, Francesco Mazzotta, Alessia Uglietti, Milena Zanzottera, Renato Maserati, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.

Original languageEnglish
Pages (from-to)1235-1239
Number of pages5
JournalJournal of Infectious Diseases
Volume203
Issue number9
DOIs
Publication statusPublished - May 1 2011

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals'. Together they form a unique fingerprint.

Cite this