Abstract
The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 1235-1239 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 203 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 1 2011 |
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ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
Cite this
Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals. / Guerini, Franca Rosa; Caputo, Sergio Lo; Gori, Andrea; Bandera, Alessandra; Mazzotta, Francesco; Uglietti, Alessia; Zanzottera, Milena; Maserati, Renato; Clerici, Mario.
In: Journal of Infectious Diseases, Vol. 203, No. 9, 01.05.2011, p. 1235-1239.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals
AU - Guerini, Franca Rosa
AU - Caputo, Sergio Lo
AU - Gori, Andrea
AU - Bandera, Alessandra
AU - Mazzotta, Francesco
AU - Uglietti, Alessia
AU - Zanzottera, Milena
AU - Maserati, Renato
AU - Clerici, Mario
PY - 2011/5/1
Y1 - 2011/5/1
N2 - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
AB - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
UR - http://www.scopus.com/inward/record.url?scp=79954605236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954605236&partnerID=8YFLogxK
U2 - 10.1093/infdis/jir020
DO - 10.1093/infdis/jir020
M3 - Article
C2 - 21398398
AN - SCOPUS:79954605236
VL - 203
SP - 1235
EP - 1239
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -