TY - JOUR
T1 - Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals
AU - Guerini, Franca Rosa
AU - Caputo, Sergio Lo
AU - Gori, Andrea
AU - Bandera, Alessandra
AU - Mazzotta, Francesco
AU - Uglietti, Alessia
AU - Zanzottera, Milena
AU - Maserati, Renato
AU - Clerici, Mario
PY - 2011/5/1
Y1 - 2011/5/1
N2 - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
AB - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
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U2 - 10.1093/infdis/jir020
DO - 10.1093/infdis/jir020
M3 - Article
C2 - 21398398
AN - SCOPUS:79954605236
VL - 203
SP - 1235
EP - 1239
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -