Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals

Franca Rosa Guerini, Sergio Lo Caputo, Andrea Gori, Alessandra Bandera, Francesco Mazzotta, Alessia Uglietti, Milena Zanzottera, Renato Maserati, Mario Clerici

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.

Original languageEnglish
Pages (from-to)1235-1239
Number of pages5
JournalJournal of Infectious Diseases
Volume203
Issue number9
DOIs
Publication statusPublished - May 1 2011

Fingerprint

HIV
Natural Killer Cells
KIR Receptors
Ligands
Molecular Typing
HLA-B Antigens
Homozygote
Alleles

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals. / Guerini, Franca Rosa; Caputo, Sergio Lo; Gori, Andrea; Bandera, Alessandra; Mazzotta, Francesco; Uglietti, Alessia; Zanzottera, Milena; Maserati, Renato; Clerici, Mario.

In: Journal of Infectious Diseases, Vol. 203, No. 9, 01.05.2011, p. 1235-1239.

Research output: Contribution to journalArticle

@article{2bfbbecab8c942e6815361fc3ef4458b,
title = "Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals",
abstract = "The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.",
author = "Guerini, {Franca Rosa} and Caputo, {Sergio Lo} and Andrea Gori and Alessandra Bandera and Francesco Mazzotta and Alessia Uglietti and Milena Zanzottera and Renato Maserati and Mario Clerici",
year = "2011",
month = "5",
day = "1",
doi = "10.1093/infdis/jir020",
language = "English",
volume = "203",
pages = "1235--1239",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals

AU - Guerini, Franca Rosa

AU - Caputo, Sergio Lo

AU - Gori, Andrea

AU - Bandera, Alessandra

AU - Mazzotta, Francesco

AU - Uglietti, Alessia

AU - Zanzottera, Milena

AU - Maserati, Renato

AU - Clerici, Mario

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.

AB - The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1+/Bw4+ inhibitory complex was reduced, whereas that of the activatory KIR3DS1+ ligand and the activatory Bw4+/3DL1-/3DS1+ complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.

UR - http://www.scopus.com/inward/record.url?scp=79954605236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954605236&partnerID=8YFLogxK

U2 - 10.1093/infdis/jir020

DO - 10.1093/infdis/jir020

M3 - Article

C2 - 21398398

AN - SCOPUS:79954605236

VL - 203

SP - 1235

EP - 1239

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 9

ER -