TY - JOUR
T1 - Underestimated collateral effects of antibiotic therapy in prosthesis-associated bacterial infections
AU - Baldassarri, Lucilla
AU - Montanaro, L.
AU - Creti, R.
AU - Arciola, C. R.
PY - 2007/9
Y1 - 2007/9
N2 - Antibiotic treatment of infections associated with the use of indwelling medical devices in ageing and/or severely ill patients represents a significant healthcare problem due to the difficulty of treating such infections and to the various collateral effects that may be observed following the often aggressive therapy. We summarize some effects of antibiotics on the expression of virulence factors of the microorganisms which cause such infections. These effects, particularly those resulting in a stimulation of bacterial virulence, might be usefully included among the other well-known collateral effects of antibiotic therapy.
AB - Antibiotic treatment of infections associated with the use of indwelling medical devices in ageing and/or severely ill patients represents a significant healthcare problem due to the difficulty of treating such infections and to the various collateral effects that may be observed following the often aggressive therapy. We summarize some effects of antibiotics on the expression of virulence factors of the microorganisms which cause such infections. These effects, particularly those resulting in a stimulation of bacterial virulence, might be usefully included among the other well-known collateral effects of antibiotic therapy.
KW - Antibiotic therapy
KW - Biomaterial-associated infections
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=36048930371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048930371&partnerID=8YFLogxK
M3 - Article
C2 - 17918123
AN - SCOPUS:36048930371
VL - 30
SP - 786
EP - 791
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 9
ER -