Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the underestimation rate and clinical relevance of lobular neoplasia in vacuum-assisted breast biopsy (VABB). Methods: A total of 161 cases of LN were retrieved from 6,435 VABB. The histological diagnosis was ALH (atypical lobular hyperplasia) in 80 patients, LCIS (lobular carcinoma in situ) in 69 patients and PLCIS (pleomorphic lobular carcinoma in situ) in 12 patients. Seventy-six patients were operated on within 2 years after VABB and 85 were clinically and radiologically monitored. The mean follow-up was 5.2 years, and the prevalence of malignancy was evaluated in the group of 85 patients. Results: The clinico-pathological characteristics significantly favouring surgery were larger lesions, occurrence of a residual lesion following VABB and histological LCIS and PLCIS subtypes. The VABB underestimation rate as compared to surgery was 7.1 % for ALH, 12 % for LCIS and 50 % for PLCIS. Overall, 11 of the 148 patients included in this survival analysis developed an ipsilateral tumour. Conclusion: Although obtained retrospectively in a relatively small series of patients, our data suggest that only patients with a diagnosis of PLCIS in VABB should be treated with surgery, whereas patients with ALH and LCIS could be monitored by clinical and radiological examinations. Key Points: • The treatment of ALH and LCIS in VABB is still debated • Some authors favour radical treatment and others a more conservative approach • Only patients with PLCIS in VABB should be treated by surgery.

Original languageEnglish
Pages (from-to)1651-1658
Number of pages8
JournalEuropean Radiology
Volume24
Issue number7
DOIs
Publication statusPublished - 2014

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Vacuum
Breast
Biopsy
Neoplasms
Hyperplasia
Breast Carcinoma In Situ
Survival Analysis
Therapeutics

Keywords

  • Breast cancer
  • Breast carcinoma in situ
  • Lobular neoplasia
  • Non-palpable breast lesions
  • Vacuum-assisted breast biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

@article{6af7262c0c804915b96c0c53088cff8e,
title = "Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy",
abstract = "Objectives: To evaluate the underestimation rate and clinical relevance of lobular neoplasia in vacuum-assisted breast biopsy (VABB). Methods: A total of 161 cases of LN were retrieved from 6,435 VABB. The histological diagnosis was ALH (atypical lobular hyperplasia) in 80 patients, LCIS (lobular carcinoma in situ) in 69 patients and PLCIS (pleomorphic lobular carcinoma in situ) in 12 patients. Seventy-six patients were operated on within 2 years after VABB and 85 were clinically and radiologically monitored. The mean follow-up was 5.2 years, and the prevalence of malignancy was evaluated in the group of 85 patients. Results: The clinico-pathological characteristics significantly favouring surgery were larger lesions, occurrence of a residual lesion following VABB and histological LCIS and PLCIS subtypes. The VABB underestimation rate as compared to surgery was 7.1 {\%} for ALH, 12 {\%} for LCIS and 50 {\%} for PLCIS. Overall, 11 of the 148 patients included in this survival analysis developed an ipsilateral tumour. Conclusion: Although obtained retrospectively in a relatively small series of patients, our data suggest that only patients with a diagnosis of PLCIS in VABB should be treated with surgery, whereas patients with ALH and LCIS could be monitored by clinical and radiological examinations. Key Points: • The treatment of ALH and LCIS in VABB is still debated • Some authors favour radical treatment and others a more conservative approach • Only patients with PLCIS in VABB should be treated by surgery.",
keywords = "Breast cancer, Breast carcinoma in situ, Lobular neoplasia, Non-palpable breast lesions, Vacuum-assisted breast biopsy",
author = "Meroni Stefano and Carla, {Bozzini Anna} and Pruneri Giancarlo and Codrina, {Moscovici Oana} and Maisonneuve Patrick and Menna Simona and Penco Silvia and Meneghetti Lorenza and Renne Giuseppe and Cassano Enrico",
year = "2014",
doi = "10.1007/s00330-014-3132-y",
language = "English",
volume = "24",
pages = "1651--1658",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "7",

}

TY - JOUR

T1 - Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy

AU - Stefano, Meroni

AU - Carla, Bozzini Anna

AU - Giancarlo, Pruneri

AU - Codrina, Moscovici Oana

AU - Patrick, Maisonneuve

AU - Simona, Menna

AU - Silvia, Penco

AU - Lorenza, Meneghetti

AU - Giuseppe, Renne

AU - Enrico, Cassano

PY - 2014

Y1 - 2014

N2 - Objectives: To evaluate the underestimation rate and clinical relevance of lobular neoplasia in vacuum-assisted breast biopsy (VABB). Methods: A total of 161 cases of LN were retrieved from 6,435 VABB. The histological diagnosis was ALH (atypical lobular hyperplasia) in 80 patients, LCIS (lobular carcinoma in situ) in 69 patients and PLCIS (pleomorphic lobular carcinoma in situ) in 12 patients. Seventy-six patients were operated on within 2 years after VABB and 85 were clinically and radiologically monitored. The mean follow-up was 5.2 years, and the prevalence of malignancy was evaluated in the group of 85 patients. Results: The clinico-pathological characteristics significantly favouring surgery were larger lesions, occurrence of a residual lesion following VABB and histological LCIS and PLCIS subtypes. The VABB underestimation rate as compared to surgery was 7.1 % for ALH, 12 % for LCIS and 50 % for PLCIS. Overall, 11 of the 148 patients included in this survival analysis developed an ipsilateral tumour. Conclusion: Although obtained retrospectively in a relatively small series of patients, our data suggest that only patients with a diagnosis of PLCIS in VABB should be treated with surgery, whereas patients with ALH and LCIS could be monitored by clinical and radiological examinations. Key Points: • The treatment of ALH and LCIS in VABB is still debated • Some authors favour radical treatment and others a more conservative approach • Only patients with PLCIS in VABB should be treated by surgery.

AB - Objectives: To evaluate the underestimation rate and clinical relevance of lobular neoplasia in vacuum-assisted breast biopsy (VABB). Methods: A total of 161 cases of LN were retrieved from 6,435 VABB. The histological diagnosis was ALH (atypical lobular hyperplasia) in 80 patients, LCIS (lobular carcinoma in situ) in 69 patients and PLCIS (pleomorphic lobular carcinoma in situ) in 12 patients. Seventy-six patients were operated on within 2 years after VABB and 85 were clinically and radiologically monitored. The mean follow-up was 5.2 years, and the prevalence of malignancy was evaluated in the group of 85 patients. Results: The clinico-pathological characteristics significantly favouring surgery were larger lesions, occurrence of a residual lesion following VABB and histological LCIS and PLCIS subtypes. The VABB underestimation rate as compared to surgery was 7.1 % for ALH, 12 % for LCIS and 50 % for PLCIS. Overall, 11 of the 148 patients included in this survival analysis developed an ipsilateral tumour. Conclusion: Although obtained retrospectively in a relatively small series of patients, our data suggest that only patients with a diagnosis of PLCIS in VABB should be treated with surgery, whereas patients with ALH and LCIS could be monitored by clinical and radiological examinations. Key Points: • The treatment of ALH and LCIS in VABB is still debated • Some authors favour radical treatment and others a more conservative approach • Only patients with PLCIS in VABB should be treated by surgery.

KW - Breast cancer

KW - Breast carcinoma in situ

KW - Lobular neoplasia

KW - Non-palpable breast lesions

KW - Vacuum-assisted breast biopsy

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U2 - 10.1007/s00330-014-3132-y

DO - 10.1007/s00330-014-3132-y

M3 - Article

C2 - 24744196

AN - SCOPUS:84902368638

VL - 24

SP - 1651

EP - 1658

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 7

ER -