Underexpression of the apolipoprotein E4 isoform in an Italian population

R. W. James, M. Boemi, R. Giansanti, P. Fumelli, D. Pometta

Research output: Contribution to journalArticle

Abstract

Apolipoprotein (apo) E polymorphism was examined in a population of Italian blood donors. A significantly reduced frequency of the ε4 allele was observed in comparison to a combined Caucasian population. Apo E polymorphism was also associated with significant differences in plasma lipid and lipoprotein levels. Notably, total and low-density lipoprotein cholesterol as well as triglycerides were increased, whereas high-density lipoprotein cholesterol was decreased in carriers of the E4 isoform. This is the first report of a significantly lower frequency of the apo E4 isoform in a European population. The reduced occurrence of an apo E isoform, which is associated with a more atherogenic lipid/lipoprotein profile, may be a contributory factor to the relatively lower incidence of cardiovascular disease in the Italian population.

Original languageEnglish
Pages (from-to)1456-1459
Number of pages4
JournalArteriosclerosis and Thrombosis
Volume13
Issue number10
Publication statusPublished - 1993

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Keywords

  • apo E
  • cardiovascular risk factors
  • cholesterol
  • lipoproteins
  • triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

James, R. W., Boemi, M., Giansanti, R., Fumelli, P., & Pometta, D. (1993). Underexpression of the apolipoprotein E4 isoform in an Italian population. Arteriosclerosis and Thrombosis, 13(10), 1456-1459.