Abstract
Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting β cells in the pancreatic islets. Although this is a polygenic disease, with at least 20 genes implicated, the dominant susceptibility locus maps to the major histocompatibility complex (MHC), both in humans and in rodent models. However, in spite of progress on several fronts, the molecular pathology of autoimmune diabetes remains incompletely defined. Major areas of research include environmental trigger factors, the identification and role of β-cell antigens in inducing and maintaining the autoimmune response, and the nature of the pathogenic and protective lymphocytes involved. In this review, we will focus on these areas to highlight recent advances in understanding the pathogenesis of autoimmune diabetes, drawing extensively on insights gained by studying the non-obese diabetic (NOD) mouse.
| Original language | English |
|---|---|
| Pages (from-to) | 31-38 |
| Number of pages | 8 |
| Journal | Trends in Molecular Medicine |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Understanding autoimmune diabetes : Insights from mouse models. / Adorini, Luciano; Gregori, Silvia; Harrison, Leonard C.
In: Trends in Molecular Medicine, Vol. 8, No. 1, 2002, p. 31-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Understanding autoimmune diabetes
T2 - Insights from mouse models
AU - Adorini, Luciano
AU - Gregori, Silvia
AU - Harrison, Leonard C.
PY - 2002
Y1 - 2002
N2 - Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting β cells in the pancreatic islets. Although this is a polygenic disease, with at least 20 genes implicated, the dominant susceptibility locus maps to the major histocompatibility complex (MHC), both in humans and in rodent models. However, in spite of progress on several fronts, the molecular pathology of autoimmune diabetes remains incompletely defined. Major areas of research include environmental trigger factors, the identification and role of β-cell antigens in inducing and maintaining the autoimmune response, and the nature of the pathogenic and protective lymphocytes involved. In this review, we will focus on these areas to highlight recent advances in understanding the pathogenesis of autoimmune diabetes, drawing extensively on insights gained by studying the non-obese diabetic (NOD) mouse.
AB - Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting β cells in the pancreatic islets. Although this is a polygenic disease, with at least 20 genes implicated, the dominant susceptibility locus maps to the major histocompatibility complex (MHC), both in humans and in rodent models. However, in spite of progress on several fronts, the molecular pathology of autoimmune diabetes remains incompletely defined. Major areas of research include environmental trigger factors, the identification and role of β-cell antigens in inducing and maintaining the autoimmune response, and the nature of the pathogenic and protective lymphocytes involved. In this review, we will focus on these areas to highlight recent advances in understanding the pathogenesis of autoimmune diabetes, drawing extensively on insights gained by studying the non-obese diabetic (NOD) mouse.
UR - http://www.scopus.com/inward/record.url?scp=0036137987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036137987&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(01)02193-1
DO - 10.1016/S1471-4914(01)02193-1
M3 - Article
C2 - 11796264
AN - SCOPUS:0036137987
VL - 8
SP - 31
EP - 38
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 1
ER -