Understanding autoimmune diabetes: Insights from mouse models

Luciano Adorini, Silvia Gregori, Leonard C. Harrison

Research output: Contribution to journalArticle

Abstract

Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting β cells in the pancreatic islets. Although this is a polygenic disease, with at least 20 genes implicated, the dominant susceptibility locus maps to the major histocompatibility complex (MHC), both in humans and in rodent models. However, in spite of progress on several fronts, the molecular pathology of autoimmune diabetes remains incompletely defined. Major areas of research include environmental trigger factors, the identification and role of β-cell antigens in inducing and maintaining the autoimmune response, and the nature of the pathogenic and protective lymphocytes involved. In this review, we will focus on these areas to highlight recent advances in understanding the pathogenesis of autoimmune diabetes, drawing extensively on insights gained by studying the non-obese diabetic (NOD) mouse.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalTrends in Molecular Medicine
Volume8
Issue number1
DOIs
Publication statusPublished - 2002

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Type 1 Diabetes Mellitus
Dominant Genes
Inbred NOD Mouse
Molecular Pathology
Insulin-Secreting Cells
Major Histocompatibility Complex
Autoimmunity
Islets of Langerhans
Autoimmune Diseases
Rodentia
Lymphocytes
Insulin
Antigens
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Understanding autoimmune diabetes : Insights from mouse models. / Adorini, Luciano; Gregori, Silvia; Harrison, Leonard C.

In: Trends in Molecular Medicine, Vol. 8, No. 1, 2002, p. 31-38.

Research output: Contribution to journalArticle

Adorini, Luciano ; Gregori, Silvia ; Harrison, Leonard C. / Understanding autoimmune diabetes : Insights from mouse models. In: Trends in Molecular Medicine. 2002 ; Vol. 8, No. 1. pp. 31-38.
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