Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni, Roberta Onesimo, Valentina Giorgio, Antonella Diamanti, Daniela Giorgio, Lucilla Martini, Aurora Rossodivita, Marco Tartaglia, Giuseppe Zampino

Research output: Contribution to journalArticlepeer-review

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

Original languageEnglish
Pages (from-to)322-324
Number of pages3
JournalJournal of Pediatrics
Volume170
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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