Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni; Roberta Onesimo; Valentina Giorgio; Antonella Diamanti; Daniela Giorgio; Lucilla Martini; Aurora Rossodivita; Marco Tartaglia; Giuseppe Zampino

doi:10.1016/j.jpeds.2015.11.076

Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni, Roberta Onesimo, Valentina Giorgio, Antonella Diamanti, Daniela Giorgio, Lucilla Martini, Aurora Rossodivita, Marco Tartaglia, Giuseppe Zampino

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

Original language	English
Pages (from-to)	322-324
Number of pages	3
Journal	Journal of Pediatrics
Volume	170
DOIs	https://doi.org/10.1016/j.jpeds.2015.11.076
Publication status	Published - Mar 1 2016

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2015.11.076

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Understanding Growth Failure in Costello Syndrome : Increased Resting Energy Expenditure. / Leoni, Chiara; Onesimo, Roberta; Giorgio, Valentina; Diamanti, Antonella; Giorgio, Daniela; Martini, Lucilla; Rossodivita, Aurora; Tartaglia, Marco; Zampino, Giuseppe.

In: Journal of Pediatrics, Vol. 170, 01.03.2016, p. 322-324.

Research output: Contribution to journal › Article › peer-review

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AU - Martini, Lucilla

AU - Rossodivita, Aurora

AU - Tartaglia, Marco

AU - Zampino, Giuseppe

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AB - Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

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Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Abstract

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