Abstract
The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 2-5 |
| Number of pages | 4 |
| Journal | Immunology Letters |
| Volume | 155 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Sep 2013 |
Fingerprint
Keywords
- Allogeneic HSC transplantation
- NK cell differentiation
- NK cells
- NK receptors
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Understanding human NK cell differentiation : Clues for improving the haploidentical hematopoietic stem cell transplantation. / Montaldo, Elisa; Vacca, Paola; Moretta, Lorenzo; Mingari, Maria Cristina.
In: Immunology Letters, Vol. 155, No. 1-2, 09.2013, p. 2-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Understanding human NK cell differentiation
T2 - Clues for improving the haploidentical hematopoietic stem cell transplantation
AU - Montaldo, Elisa
AU - Vacca, Paola
AU - Moretta, Lorenzo
AU - Mingari, Maria Cristina
PY - 2013/9
Y1 - 2013/9
N2 - The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
AB - The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
KW - Allogeneic HSC transplantation
KW - NK cell differentiation
KW - NK cells
KW - NK receptors
UR - http://www.scopus.com/inward/record.url?scp=84887822968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887822968&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2013.09.022
DO - 10.1016/j.imlet.2013.09.022
M3 - Article
VL - 155
SP - 2
EP - 5
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 1-2
ER -