Understanding human NK cell differentiation: Clues for improving the haploidentical hematopoietic stem cell transplantation

Elisa Montaldo, Paola Vacca, Lorenzo Moretta, Maria Cristina Mingari

Research output: Contribution to journalArticlepeer-review

Abstract

The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalImmunology Letters
Volume155
Issue number1-2
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Allogeneic HSC transplantation
  • NK cell differentiation
  • NK cells
  • NK receptors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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