Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

Niki Karachaliou, Maria Gonzalez Cao, Cristina Teixidó, Santiago Viteri, Daniela Morales-Espinosa, Mariacarmela Santarpia, Rafael Rosell

Research output: Contribution to journalArticlepeer-review

Abstract

Survival rates for metastatic lung cancer, including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), are poor with 5-year survivals of less than 5%. The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer progresses and presenting new ways to halt disease progress. Due to the extraordinary power of the immune system-with its capacity for memory, exquisite specificity and central and universal role in human biology-immunotherapy has the potential to achieve complete, long-lasting remissions and cures, with few side effects for any cancer patient, regardless of cancer type. As a result, a range of cancer therapies are under development that work by turning our own immune cells against tumors. However deeper understanding of the complexity of immunomodulation by tumors is key to the development of effective immunotherapies, especially in lung cancer.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalCancer Biology and Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Immune checkpoint
  • Immunotherapy
  • Lung cancer
  • Program death-1 (PD-1)
  • Program death-ligand 1 (PD-L1)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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