Unexpected association between joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type and obsessive-compulsive personality disorder

Massimo Pasquini, Claudia Celletti, Isabella Berardelli, Valentina Roselli, Simona Mastroeni, Marco Castori, Massimo Biondi, Filippo Camerota

Research output: Contribution to journalArticle

Abstract

Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, mainly characterized by joint instability complications, widespread musculoskeletal pain, and minor skin features. In a case-control study, 47 consecutive JHS/EDS-HT patients were investigated for the prevalence of psychiatric disorders and compared to 45 healthy controls in a single center. The psychiatric evaluation consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of Functioning Scale (GAF) was used to assess the overall severity of psychological, social, and occupational functions. JHS/EDS-HT patients had significantly higher mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher risk of being affected by any psychiatric disorder, and in particular, a 5.8 higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT suffered from obsessive-compulsive personality disorder with an observed prevalence rate of 10.6 % (3.6-23.1). Psychiatric assessment of JHS/EDS-HT patients showed an extremely high prevalence of personality disorders (21 %), and of Axis-I disorders (38 %), mostly depressive. This study did not confirm the previously reported increased rate of panic disorders in JHS/EDS-HT.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalRheumatology International
Volume34
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Compulsive Personality Disorder
Joint Instability
Obsessive-Compulsive Disorder
Psychiatry
Brief Psychiatric Rating Scale
Personality Disorders
Musculoskeletal Pain
Ehlers-Danlos syndrome type 3
Panic Disorder
Diagnostic and Statistical Manual of Mental Disorders
Connective Tissue
Case-Control Studies
Anxiety
Interviews
Depression
Psychology
Skin

Keywords

  • Anxiety disorder
  • Connective tissue disorder
  • Depressive disorder
  • Ehlers-Danlos syndrome
  • Joint hypermobility
  • Obsessive-compulsive personality disorder
  • Personality disorder

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Unexpected association between joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type and obsessive-compulsive personality disorder. / Pasquini, Massimo; Celletti, Claudia; Berardelli, Isabella; Roselli, Valentina; Mastroeni, Simona; Castori, Marco; Biondi, Massimo; Camerota, Filippo.

In: Rheumatology International, Vol. 34, No. 5, 2014, p. 631-636.

Research output: Contribution to journalArticle

Pasquini, Massimo ; Celletti, Claudia ; Berardelli, Isabella ; Roselli, Valentina ; Mastroeni, Simona ; Castori, Marco ; Biondi, Massimo ; Camerota, Filippo. / Unexpected association between joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type and obsessive-compulsive personality disorder. In: Rheumatology International. 2014 ; Vol. 34, No. 5. pp. 631-636.
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abstract = "Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, mainly characterized by joint instability complications, widespread musculoskeletal pain, and minor skin features. In a case-control study, 47 consecutive JHS/EDS-HT patients were investigated for the prevalence of psychiatric disorders and compared to 45 healthy controls in a single center. The psychiatric evaluation consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of Functioning Scale (GAF) was used to assess the overall severity of psychological, social, and occupational functions. JHS/EDS-HT patients had significantly higher mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher risk of being affected by any psychiatric disorder, and in particular, a 5.8 higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT suffered from obsessive-compulsive personality disorder with an observed prevalence rate of 10.6 {\%} (3.6-23.1). Psychiatric assessment of JHS/EDS-HT patients showed an extremely high prevalence of personality disorders (21 {\%}), and of Axis-I disorders (38 {\%}), mostly depressive. This study did not confirm the previously reported increased rate of panic disorders in JHS/EDS-HT.",
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AU - Camerota, Filippo

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