Unexpected clinical outcome in a patient with liver and brain metastasis from melanoma

Carmen Nuzzo; Massimo Zeuli; Virginia Ferraresi; Mariangela Ciccarese; Domenica Pelligrini; Francesco Cognetti

Unexpected clinical outcome in a patient with liver and brain metastasis from melanoma

Carmen Nuzzo, Massimo Zeuli, Virginia Ferraresi, Mariangela Ciccarese, Domenica Pelligrini, Francesco Cognetti

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The treatment of disseminated melanoma is inadequate. The most active single agents provide brief objective response in 20% of patients, while the combination chemotherapy improves response rates without any apparent survival benefit. Median overall survival is, in fact, 7-9 months and 5 year survival is approximately 6%. Metastatic melanoma with a localization of the disease in the liver and brain are categorized as M1c and have the worst prognosis. Here we describe the history, treatment and favourable clinical outcome in a young man with liver and resected brain metastases who obtained complete remission for 6 years since chemotherapy with dacarbazine, cisplatin and vinblastine.

Original language	English
Pages (from-to)	1429-1431
Number of pages	3
Journal	Anticancer Research
Volume	28
Issue number	2 B
Publication status	Published - Mar 2008

Keywords

Long-term survival
Melanoma
Metastatic disease

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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T1 - Unexpected clinical outcome in a patient with liver and brain metastasis from melanoma

AU - Nuzzo, Carmen

AU - Zeuli, Massimo

AU - Ferraresi, Virginia

AU - Ciccarese, Mariangela

AU - Pelligrini, Domenica

AU - Cognetti, Francesco

PY - 2008/3

Y1 - 2008/3

N2 - The treatment of disseminated melanoma is inadequate. The most active single agents provide brief objective response in 20% of patients, while the combination chemotherapy improves response rates without any apparent survival benefit. Median overall survival is, in fact, 7-9 months and 5 year survival is approximately 6%. Metastatic melanoma with a localization of the disease in the liver and brain are categorized as M1c and have the worst prognosis. Here we describe the history, treatment and favourable clinical outcome in a young man with liver and resected brain metastases who obtained complete remission for 6 years since chemotherapy with dacarbazine, cisplatin and vinblastine.

AB - The treatment of disseminated melanoma is inadequate. The most active single agents provide brief objective response in 20% of patients, while the combination chemotherapy improves response rates without any apparent survival benefit. Median overall survival is, in fact, 7-9 months and 5 year survival is approximately 6%. Metastatic melanoma with a localization of the disease in the liver and brain are categorized as M1c and have the worst prognosis. Here we describe the history, treatment and favourable clinical outcome in a young man with liver and resected brain metastases who obtained complete remission for 6 years since chemotherapy with dacarbazine, cisplatin and vinblastine.

KW - Long-term survival

KW - Melanoma

KW - Metastatic disease

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SN - 0250-7005

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ER -

Unexpected clinical outcome in a patient with liver and brain metastasis from melanoma

Abstract

Keywords

ASJC Scopus subject areas

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