Abstract
Background: Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma. Objective: To investigate the occurrence of BRAF and cKIT impairments in patients with sinonasal melanoma in Southern Italy. Methods: Eleven sinonasal melanomas were screened for BRAF mutations and cKIT alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses. Results: A high prevalence (4/11; 36%) of BRAF mutations and lack of cKIT mutations were observed. Amplification of cKIT was found in 18% of cases; cKIT expression was detectable in 18% non-overlapping cases. No correlation between CD117 and cKIT alterations was observed. One (6%) cKIT and two (12%) BRAF mutations were detected in an additional series of 17 acral/mucosal melanomas from the same geographic areas. Conclusion: Mutations of cKIT are infrequent in sinonasal melanoma in Southern Italy.
Original language | English |
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Pages (from-to) | 279-284 |
Number of pages | 6 |
Journal | Dermatology |
Volume | 226 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- BRAF
- cKIT
- Melanoma
- Mutation analysis
- Sinonasal
ASJC Scopus subject areas
- Dermatology