Unexpected dramatic increase in CD4+ cell count in a patient with AIDS after enfuvirtide treatment despite persistent viremia and resistance mutations

Alessandro Soria, Mariangela Cavarelli, Stefania Sala, Anna Ida Alessandrini, Gabriella Scarlatti, Adriano Lazzarin, Antonella Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

An unexpected dramatic immune recovery was observed in a patient with full-blown AIDS receiving enfuvirtide-based antiretroviral therapy after multiple treatment failures. A complex interplay of viral and host factors, including the control of X4 viruses and proviral burden, may favor immune restoration with HIV neutralizing activity, despite persistent viremia.

Original languageEnglish
Pages (from-to)937-941
Number of pages5
JournalJournal of Medical Virology
Volume80
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • AIDS
  • Enfuvirtide
  • Immune recovery
  • Multi-drug resistance

ASJC Scopus subject areas

  • Virology

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