TY - JOUR
T1 - Unexpected healing of cutaneous ulcers in a short child
AU - Cimaz, Rolando
AU - Rusconi, Roberto
AU - Fossali, Emilio
AU - Careddu, Paolo
PY - 2001/7/21
Y1 - 2001/7/21
N2 - A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.
AB - A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.
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U2 - 10.1016/S0140-6736(01)05413-7
DO - 10.1016/S0140-6736(01)05413-7
M3 - Article
C2 - 11476842
AN - SCOPUS:0035928410
VL - 358
SP - 211
EP - 212
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9277
ER -