Unexpected low efficacy of stealth liposomal doxorubicin (Caelyx) and vinorelbine in metastatic breast cancer

Lorenza Rimassa, Carlo Carnaghi, Isabella Garassino, Piermario Salvini, Valeria Ginanni, Giuseppe Gullo, Emanuela Morenghi, Armando Santoro

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Abstract

In this phase II study, 23 patients with metastatic breast cancer were treated with a combination of Caelyx (40 mg/m 2 on day 1) and vinorelbine (20 mg/m 2 on days 1 and 8) every 4 weeks. According to the statistical design, enrollment was closed after the first stage due to the low response rate observed (four partial remissions, 12 stabilizations). Toxicity was acceptable, however, grade 3-4 neutropenia was not negligible. Our study does not support the development of this combination in advanced breast cancer.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalBreast Cancer Research and Treatment
Volume77
Issue number2
DOIs
Publication statusPublished - Jan 2003

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Keywords

  • Advanced breast cancer
  • Caelyx
  • Doxorubicin
  • Pegylated liposomal
  • Vinorelbine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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