Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection

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Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.

Original languageEnglish
JournalTherapeutic Advances in Medical Oncology
Publication statusPublished - 2021


  • chemotherapy
  • colorectal cancer
  • COVID-19
  • NK cells
  • SARS-CoV-2

ASJC Scopus subject areas

  • Oncology

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