Unexplained infertility: a review of diagnosis, prognosis, treatment efficacy and management

J. A. Collins, P. G. Crosignani

Research output: Contribution to journalArticlepeer-review


The dilemma of unexplained infertility posed by Southam in 1960 remains today: despite advances in the diagnostic assessment of infertility, many couples still have no explanation for their infertility. Even the most sophisticated evaluation of semen, ovulation and genital tract competence cannot reveal all of the possible defects in the complex process leading to conception. Because it arises from these shortcomings in our knowledge of fertilization and from our inability to utilize all of the current knowledge, unexplained infertility is a challenge for both biological and clinical research. This paper attempts to summarize some clinical issues in the management of unexplained infertility: the prevalence of the disorder, problems in the definition and possible explanations for the existence of this diagnostic category. It reviews outcome-based clinical publications as a guide to decision-making on what diagnostic tests to use, provides a summary of the untreated prognosis and evaluates study results that may serve as a basis for treatment decisions in this puzzling diagnostic category of infertility.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalInternational Journal of Gynecology and Obstetrics
Issue number4
Publication statusPublished - 1992


  • Diagnosis
  • Epidemiology
  • Pregnancy
  • Treatment
  • Unexplained infertility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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