Unfavourable gender effect of high body mass index on brain metabolism and connectivity

M Malpetti, A Sala, EG Vanoli, L Gianolli, L Luzi, D Perani

Research output: Contribution to journalArticle

Abstract

The influence of Body Mass Index (BMI) on neurodegeneration in dementia has yet to be elucidated. We aimed at exploring the effects of BMI levels on cerebral resting-state metabolism and brain connectivity, as crucial measures of synaptic function and activity, in a large group of patients with Alzheimer’s Dementia (AD) (n = 206), considering gender. We tested the correlation between BMI levels and brain metabolism, as assessed by18F-FDG-PET, and the modulation of the resting-state functional networks by BMI. At comparable dementia severity, females with high BMI can withstand a lower degree of brain metabolism dysfunction, as shown by a significant BMI-brain metabolism correlation in the temporal-parietal regions, which are typically vulnerable to AD pathology (R = 0.269, p = 0.009). Of note, high BMI was also associated with reduced connectivity in frontal and limbic brain networks, again only in AD females (p <0.05 FDR-corrected, k = 100 voxels). This suggests a major vulnerability of neural systems known to be selectively involved in brain compensatory mechanisms in AD females. These findings indicate a strong gender effect of high BMI and obesity in AD, namely reducing the available reserve mechanisms in female patients. This brings to considerations for medical practice and health policy. © 2018, The Author(s).
Original languageEnglish
Article number12584
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 2018

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Body Mass Index
Brain
Alzheimer Disease
Dementia
Parietal Lobe
Temporal Lobe
Health Policy
Obesity
Pathology

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Unfavourable gender effect of high body mass index on brain metabolism and connectivity. / Malpetti, M; Sala, A; Vanoli, EG; Gianolli, L; Luzi, L; Perani, D.

In: Scientific Reports, Vol. 8, 12584, 2018.

Research output: Contribution to journalArticle

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