Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling

Matteo Piazza, Miriam Colombo, Ivan Zanoni, Francesca Granucci, Paolo Tortora, Jerrold Weiss, Theresa Gioannini, Davide Prosperi, Francesco Peri

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture).

Original languageEnglish
Pages (from-to)622-626
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number3
DOIs
Publication statusPublished - Jan 17 2011

Fingerprint

Toll-Like Receptor 4
Lipopolysaccharides
Nanoparticles
Iron oxides
Chemical activation
Molecules
Water

Keywords

  • endotoxin
  • immunology
  • lipopolysaccharides
  • nanoparticles
  • receptors

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling. / Piazza, Matteo; Colombo, Miriam; Zanoni, Ivan; Granucci, Francesca; Tortora, Paolo; Weiss, Jerrold; Gioannini, Theresa; Prosperi, Davide; Peri, Francesco.

In: Angewandte Chemie - International Edition, Vol. 50, No. 3, 17.01.2011, p. 622-626.

Research output: Contribution to journalArticle

Piazza, M, Colombo, M, Zanoni, I, Granucci, F, Tortora, P, Weiss, J, Gioannini, T, Prosperi, D & Peri, F 2011, 'Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling', Angewandte Chemie - International Edition, vol. 50, no. 3, pp. 622-626. https://doi.org/10.1002/anie.201004655
Piazza, Matteo ; Colombo, Miriam ; Zanoni, Ivan ; Granucci, Francesca ; Tortora, Paolo ; Weiss, Jerrold ; Gioannini, Theresa ; Prosperi, Davide ; Peri, Francesco. / Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 3. pp. 622-626.
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