Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling

Matteo Piazza, Miriam Colombo, Ivan Zanoni, Francesca Granucci, Paolo Tortora, Jerrold Weiss, Theresa Gioannini, Davide Prosperi, Francesco Peri

Research output: Contribution to journalArticlepeer-review

Abstract

Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture).

Original languageEnglish
Pages (from-to)622-626
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number3
DOIs
Publication statusPublished - Jan 17 2011

Keywords

  • endotoxin
  • immunology
  • lipopolysaccharides
  • nanoparticles
  • receptors

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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