Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus improves oromotor movements in Parkinson's disease

Paolo Mazzone, Luca Padua, Gianni Falisi, Angelo Insola, Tiziana M. Florio, Eugenio Scarnati

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Jaw movements are severely affected in Parkinson's disease. Deep brain stimulation (DBS) of basal ganglia targets is known to ameliorate oromotor control. In this study, we examined the effects of DBS of the pedunculopontine tegmental nucleus (PPTg) on jaw movements in selected parkinsonian patients. Methods: The effects of low-frequency (25 Hz) stimulation of the PPTg on jaw movements were investigated through electrognathographic analysis in parkinsonian patients who were selected for PPTg stimulation. Changes in jaw velocity and amplitude during voluntary opening and closing movements of the mouth, as well as the maximum frequency of self-paced sequences of opening and closing cycles, were analyzed. Results: Low-frequency stimulation of the PPTg in the OFF-drugs condition significantly improved the opening and closing velocities, vertical amplitude and rhythm of voluntary movements. In some instances, movement parameters during stimulation were within the range of those recorded in healthy controls. Discussion: This is the first study investigating the impact of PPTg DBS on oromotor control in parkinsonian patients. The results show that jaw movements may be restored under stimulation and suggest that the pedunculopontine nucleus may play a key role in controlling oromotor activity.

Original languageEnglish
Pages (from-to)634-641
Number of pages8
JournalBrain Stimulation
Volume5
Issue number4
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Pedunculopontine Tegmental Nucleus
Deep Brain Stimulation
Jaw
Parkinson Disease
Basal Ganglia
Mouth
Pharmaceutical Preparations

Keywords

  • Deep brain stimulation
  • Jaw movements
  • Parkinson's disease
  • Pedunculopontine tegmental nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics

Cite this

Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus improves oromotor movements in Parkinson's disease. / Mazzone, Paolo; Padua, Luca; Falisi, Gianni; Insola, Angelo; Florio, Tiziana M.; Scarnati, Eugenio.

In: Brain Stimulation, Vol. 5, No. 4, 10.2012, p. 634-641.

Research output: Contribution to journalArticle

Mazzone, Paolo ; Padua, Luca ; Falisi, Gianni ; Insola, Angelo ; Florio, Tiziana M. ; Scarnati, Eugenio. / Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus improves oromotor movements in Parkinson's disease. In: Brain Stimulation. 2012 ; Vol. 5, No. 4. pp. 634-641.
@article{92caba9a2d7a481483c7f5f8ff34f1dc,
title = "Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus improves oromotor movements in Parkinson's disease",
abstract = "Background: Jaw movements are severely affected in Parkinson's disease. Deep brain stimulation (DBS) of basal ganglia targets is known to ameliorate oromotor control. In this study, we examined the effects of DBS of the pedunculopontine tegmental nucleus (PPTg) on jaw movements in selected parkinsonian patients. Methods: The effects of low-frequency (25 Hz) stimulation of the PPTg on jaw movements were investigated through electrognathographic analysis in parkinsonian patients who were selected for PPTg stimulation. Changes in jaw velocity and amplitude during voluntary opening and closing movements of the mouth, as well as the maximum frequency of self-paced sequences of opening and closing cycles, were analyzed. Results: Low-frequency stimulation of the PPTg in the OFF-drugs condition significantly improved the opening and closing velocities, vertical amplitude and rhythm of voluntary movements. In some instances, movement parameters during stimulation were within the range of those recorded in healthy controls. Discussion: This is the first study investigating the impact of PPTg DBS on oromotor control in parkinsonian patients. The results show that jaw movements may be restored under stimulation and suggest that the pedunculopontine nucleus may play a key role in controlling oromotor activity.",
keywords = "Deep brain stimulation, Jaw movements, Parkinson's disease, Pedunculopontine tegmental nucleus",
author = "Paolo Mazzone and Luca Padua and Gianni Falisi and Angelo Insola and Florio, {Tiziana M.} and Eugenio Scarnati",
year = "2012",
month = "10",
doi = "10.1016/j.brs.2012.01.002",
language = "English",
volume = "5",
pages = "634--641",
journal = "Brain Stimulation",
issn = "1935-861X",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus improves oromotor movements in Parkinson's disease

AU - Mazzone, Paolo

AU - Padua, Luca

AU - Falisi, Gianni

AU - Insola, Angelo

AU - Florio, Tiziana M.

AU - Scarnati, Eugenio

PY - 2012/10

Y1 - 2012/10

N2 - Background: Jaw movements are severely affected in Parkinson's disease. Deep brain stimulation (DBS) of basal ganglia targets is known to ameliorate oromotor control. In this study, we examined the effects of DBS of the pedunculopontine tegmental nucleus (PPTg) on jaw movements in selected parkinsonian patients. Methods: The effects of low-frequency (25 Hz) stimulation of the PPTg on jaw movements were investigated through electrognathographic analysis in parkinsonian patients who were selected for PPTg stimulation. Changes in jaw velocity and amplitude during voluntary opening and closing movements of the mouth, as well as the maximum frequency of self-paced sequences of opening and closing cycles, were analyzed. Results: Low-frequency stimulation of the PPTg in the OFF-drugs condition significantly improved the opening and closing velocities, vertical amplitude and rhythm of voluntary movements. In some instances, movement parameters during stimulation were within the range of those recorded in healthy controls. Discussion: This is the first study investigating the impact of PPTg DBS on oromotor control in parkinsonian patients. The results show that jaw movements may be restored under stimulation and suggest that the pedunculopontine nucleus may play a key role in controlling oromotor activity.

AB - Background: Jaw movements are severely affected in Parkinson's disease. Deep brain stimulation (DBS) of basal ganglia targets is known to ameliorate oromotor control. In this study, we examined the effects of DBS of the pedunculopontine tegmental nucleus (PPTg) on jaw movements in selected parkinsonian patients. Methods: The effects of low-frequency (25 Hz) stimulation of the PPTg on jaw movements were investigated through electrognathographic analysis in parkinsonian patients who were selected for PPTg stimulation. Changes in jaw velocity and amplitude during voluntary opening and closing movements of the mouth, as well as the maximum frequency of self-paced sequences of opening and closing cycles, were analyzed. Results: Low-frequency stimulation of the PPTg in the OFF-drugs condition significantly improved the opening and closing velocities, vertical amplitude and rhythm of voluntary movements. In some instances, movement parameters during stimulation were within the range of those recorded in healthy controls. Discussion: This is the first study investigating the impact of PPTg DBS on oromotor control in parkinsonian patients. The results show that jaw movements may be restored under stimulation and suggest that the pedunculopontine nucleus may play a key role in controlling oromotor activity.

KW - Deep brain stimulation

KW - Jaw movements

KW - Parkinson's disease

KW - Pedunculopontine tegmental nucleus

UR - http://www.scopus.com/inward/record.url?scp=84867574373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867574373&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2012.01.002

DO - 10.1016/j.brs.2012.01.002

M3 - Article

VL - 5

SP - 634

EP - 641

JO - Brain Stimulation

JF - Brain Stimulation

SN - 1935-861X

IS - 4

ER -