Unilateral lesion of the subthalamic nucleus enhances cortical fos expression associated with focally evoked seizures in the rat

Fabio Blandini, Roberto Fancellu, Marie Therese Armentero, Cristina Tassorelli, Rosaria Greco, Francesco Fornai, Giuseppe Nappi

Research output: Contribution to journalArticle

Abstract

Reducing subthalamic nucleus (STN) activity has been proposed as an anti-epileptic procedure. Here we show that, on the contrary, a unilateral lesion of the STN causes slight (nonsignificant) increases in the severity of limbic seizures evoked by bicuculline infusion into the piriform cortex, associated with marked Fos expression throughout the cerebral cortex. Abolishing the STN control over the basal ganglia output may therefore play a facilitatory role on cortical activation associated with limbic seizures.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalBrain Research
Volume1101
Issue number1
DOIs
Publication statusPublished - Jul 26 2006

Keywords

  • Basal ganglia
  • Bicuculline
  • Epilepsy
  • Hippocampus
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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