Abstract
The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years. Here we summarize the evidence for the existence and the biological role of such Ags in human tumors, although such evidence was provided only during the last 10 years and by a limited number of studies, a fact leading to a misrepresentation of unique Ags in human tumor immunology. This was also due to the increasing knowledge on the shared, self-human tumor Ags, which have been extensively used as cancer vaccines. In this review, we highlight the biological and clinical importance of unique Ags and suggest how they could be used in clinical studies aimed at assessing their immunogenic and clinical potential both in active and adoptive immunotherapy of human tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 1975-1979 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 178 |
| Issue number | 4 |
| Publication status | Published - Feb 15 2007 |
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ASJC Scopus subject areas
- Immunology
Cite this
Unique human tumor antigens : Immunobiology and use in clinical trials. / Parmiani, Giorgio; De Filippo, Annamaria; Novellino, Luisa; Castelli, Chiara.
In: Journal of Immunology, Vol. 178, No. 4, 15.02.2007, p. 1975-1979.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unique human tumor antigens
T2 - Immunobiology and use in clinical trials
AU - Parmiani, Giorgio
AU - De Filippo, Annamaria
AU - Novellino, Luisa
AU - Castelli, Chiara
PY - 2007/2/15
Y1 - 2007/2/15
N2 - The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years. Here we summarize the evidence for the existence and the biological role of such Ags in human tumors, although such evidence was provided only during the last 10 years and by a limited number of studies, a fact leading to a misrepresentation of unique Ags in human tumor immunology. This was also due to the increasing knowledge on the shared, self-human tumor Ags, which have been extensively used as cancer vaccines. In this review, we highlight the biological and clinical importance of unique Ags and suggest how they could be used in clinical studies aimed at assessing their immunogenic and clinical potential both in active and adoptive immunotherapy of human tumors.
AB - The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years. Here we summarize the evidence for the existence and the biological role of such Ags in human tumors, although such evidence was provided only during the last 10 years and by a limited number of studies, a fact leading to a misrepresentation of unique Ags in human tumor immunology. This was also due to the increasing knowledge on the shared, self-human tumor Ags, which have been extensively used as cancer vaccines. In this review, we highlight the biological and clinical importance of unique Ags and suggest how they could be used in clinical studies aimed at assessing their immunogenic and clinical potential both in active and adoptive immunotherapy of human tumors.
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UR - http://www.scopus.com/inward/citedby.url?scp=33846935228&partnerID=8YFLogxK
M3 - Article
C2 - 17277099
AN - SCOPUS:33846935228
VL - 178
SP - 1975
EP - 1979
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -