Unique human tumor antigens: Immunobiology and use in clinical trials

Giorgio Parmiani, Annamaria De Filippo, Luisa Novellino, Chiara Castelli

Research output: Contribution to journalArticlepeer-review

Abstract

The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years. Here we summarize the evidence for the existence and the biological role of such Ags in human tumors, although such evidence was provided only during the last 10 years and by a limited number of studies, a fact leading to a misrepresentation of unique Ags in human tumor immunology. This was also due to the increasing knowledge on the shared, self-human tumor Ags, which have been extensively used as cancer vaccines. In this review, we highlight the biological and clinical importance of unique Ags and suggest how they could be used in clinical studies aimed at assessing their immunogenic and clinical potential both in active and adoptive immunotherapy of human tumors.

Original languageEnglish
Pages (from-to)1975-1979
Number of pages5
JournalJournal of Immunology
Volume178
Issue number4
Publication statusPublished - Feb 15 2007

ASJC Scopus subject areas

  • Immunology

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