Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendothelioma: Case report

Lorenzo Cobianchi, Marco Lucioni, Renato Rosso, Sandro Zonta, Giacomo Fiandrino, Mario Alessiani, Marco Doni, Alberta Ferrari, Umberto Magrini, Marco Paulli, Paolo Dionigi

Research output: Contribution to journalArticlepeer-review

Abstract

Reported herein is an unusual vascular tumor primary arising in the liver and exhibiting unique histopathological features. A 47-year-old woman underwent left hepatectomy because of a large hepatic mass. On histology the tumor had a composite pattern, consisting of angiomatous, retiform and solid areas, formed by oval to cuboidal to spindle cells, that expressed only endothelial markers (CD31 and factor VIII-related antigen). These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called polymorphous hemangioendothelioma. The tumor was completely resected. At 24 month follow up the patient was alive, without evidence of disease. Polymorphous hemangioendothelioma is a rare vascular neoplasm, with borderline malignant potential, which usually occurs in lymph nodes and, rarely, at extranodal sites. Its classification as an entity has been questioned recently. The unusual morphological features of the present case, which do not fit neatly with any other recognized hemangioendothelioma subtype, indicate that the family of vascular tumors is broader than currently accepted. In addition the present case widens the spectrum of primary vascular tumors arising in the liver.

Original languageEnglish
Pages (from-to)890-894
Number of pages5
JournalPathology International
Volume59
Issue number12
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Immunohistochemistry
  • Liver
  • Polymorphous hemangioendothelioma
  • Vascular tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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