Universal childhood immunisation against Streptococcus pneumoniae: The five-year experience of Liguria Region, Italy

Paolo Durando, Pietro Crovari, Filippo Ansaldi, Laura Sticchi, Camilla Sticchi, Valter Turello, Lorenzo Marensi, Raffaella Giacchino, Anna Timitilli, Roberto Carloni, Chiara Azzari, Giancarlo Icardi

Research output: Contribution to journalArticlepeer-review

Abstract

Liguria was the first Italian Administrative Region, since 2003, to actively recommend free-of-charge immunisation, of all infants, with heptavalent Pneumococcal Conjugate Vaccine (PCV-7), within a research pilot-project. Vaccination coverage among infants rapidly increased from 42.8% in 2003 to 83.3% in 2004, progressively reaching levels of 93.4% in 2007. Two scientific projects have been carried out, aimed: (i) to assess the immunogenicity of PCV-7 and of a hexavalent vaccine Diphtheria-Tetanus-Trivalent Acellular Pertussis-Hepatitis B-Inactivated Polio Virus-Haemophilus influenzae type B (DTaP-HBV-IPV-Hib) when co-administered to healthy infants at 3, 5 and 11-12 months of age (routine schedule), and (ii) to evaluate the effect of the immunisation campaign in preventing pneumococcal-associated hospitalisations. Results in 151 infants showed the high immunogenicity of the vaccines, seroprotection rates, measured 1 month after the third dose, ranging between 97.3% (serotype 6 B) and 100% (serotypes 4 and 9 V) for PCV-7 and between 99.3% and 100% against common antigens of hexavalent vaccine. Monitoring nearly 70,000 children, aged 0-24 months, during the period 2000-2007, and comparing hospitalisation rates occurred in subjects belonging to birth cohorts before and after the introduction of widespread immunisation, a significant decline for all-cause and pneumococcal pneumonia and for acute otitis media was observed, with preventive fractions of 15.2%, 70.5% and 36.4%, respectively.

Original languageEnglish
Pages (from-to)3459-3462
Number of pages4
JournalVaccine
Volume27
Issue number25-26
DOIs
Publication statusPublished - May 26 2009

Keywords

  • Heptavalent pneumococcal conjugate vaccine (PCV-7)
  • Immunogenicity
  • Pneumococcal-associated hospitalisations

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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