Universal definition of perioperative bleeding in adult cardiac surgery

Cornelius Dyke, Solomon Aronson, Wulf Dietrich, Axel Hofmann, Keyvan Karkouti, Marcel Levi, Gavin J. Murphy, Frank W. Sellke, Linda Shore-Lesserson, Christian Von Heymann, Marco Ranucci

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Objectives: Perioperative bleeding is common among patients undergoing cardiac surgery; however, the definition of perioperative bleeding is variable and lacks standardization. We propose a universal definition for perioperative bleeding (UDPB) in adult cardiac surgery in an attempt to precisely describe and quantify bleeding and to facilitate future investigation into this difficult clinical problem. Methods: The multidisciplinary International Initiative on Haemostasis Management in Cardiac Surgery identified a common definition of perioperative bleeding as an unmet need. The functionality and usefulness of the UDPB for clinical research was then tested using a large single-center, nonselected, cardiac surgical database. Results: A multistaged definition for perioperative bleeding was created based on easily measured clinical end points, including total blood loss from chest tubes within 12 hours, allogeneic blood products transfused, surgical reexploration including cardiac tamponade, delayed sternal closure, and the need for salvage treatment. Depending on these components, bleeding is graded as insignificant, mild, moderate, severe, or massive. When applied to an established cardiac surgery dataset, the UDPB provided insight into the incidence and outcome of bleeding after cardiac surgery. Conclusions: The proposed UDPB in adult cardiac surgery provides a precise classification of bleeding that is useful in everyday practice as well as in clinical research. Once fully validated, the UDPB may be useful as an institutional quality measure and serve as an important end point in future cardiac surgical research.

Original languageEnglish
JournalJournal of Thoracic and Cardiovascular Surgery
Volume147
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Thoracic Surgery
Hemorrhage
Research
Salvage Therapy
Chest Tubes
Cardiac Tamponade
Hemostasis
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Universal definition of perioperative bleeding in adult cardiac surgery. / Dyke, Cornelius; Aronson, Solomon; Dietrich, Wulf; Hofmann, Axel; Karkouti, Keyvan; Levi, Marcel; Murphy, Gavin J.; Sellke, Frank W.; Shore-Lesserson, Linda; Von Heymann, Christian; Ranucci, Marco.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 147, No. 5, 2014.

Research output: Contribution to journalArticle

Dyke, C, Aronson, S, Dietrich, W, Hofmann, A, Karkouti, K, Levi, M, Murphy, GJ, Sellke, FW, Shore-Lesserson, L, Von Heymann, C & Ranucci, M 2014, 'Universal definition of perioperative bleeding in adult cardiac surgery', Journal of Thoracic and Cardiovascular Surgery, vol. 147, no. 5. https://doi.org/10.1016/j.jtcvs.2013.10.070
Dyke, Cornelius ; Aronson, Solomon ; Dietrich, Wulf ; Hofmann, Axel ; Karkouti, Keyvan ; Levi, Marcel ; Murphy, Gavin J. ; Sellke, Frank W. ; Shore-Lesserson, Linda ; Von Heymann, Christian ; Ranucci, Marco. / Universal definition of perioperative bleeding in adult cardiac surgery. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 147, No. 5.
@article{577e4bed0b74440d8e80e0b28c34fb49,
title = "Universal definition of perioperative bleeding in adult cardiac surgery",
abstract = "Objectives: Perioperative bleeding is common among patients undergoing cardiac surgery; however, the definition of perioperative bleeding is variable and lacks standardization. We propose a universal definition for perioperative bleeding (UDPB) in adult cardiac surgery in an attempt to precisely describe and quantify bleeding and to facilitate future investigation into this difficult clinical problem. Methods: The multidisciplinary International Initiative on Haemostasis Management in Cardiac Surgery identified a common definition of perioperative bleeding as an unmet need. The functionality and usefulness of the UDPB for clinical research was then tested using a large single-center, nonselected, cardiac surgical database. Results: A multistaged definition for perioperative bleeding was created based on easily measured clinical end points, including total blood loss from chest tubes within 12 hours, allogeneic blood products transfused, surgical reexploration including cardiac tamponade, delayed sternal closure, and the need for salvage treatment. Depending on these components, bleeding is graded as insignificant, mild, moderate, severe, or massive. When applied to an established cardiac surgery dataset, the UDPB provided insight into the incidence and outcome of bleeding after cardiac surgery. Conclusions: The proposed UDPB in adult cardiac surgery provides a precise classification of bleeding that is useful in everyday practice as well as in clinical research. Once fully validated, the UDPB may be useful as an institutional quality measure and serve as an important end point in future cardiac surgical research.",
author = "Cornelius Dyke and Solomon Aronson and Wulf Dietrich and Axel Hofmann and Keyvan Karkouti and Marcel Levi and Murphy, {Gavin J.} and Sellke, {Frank W.} and Linda Shore-Lesserson and {Von Heymann}, Christian and Marco Ranucci",
year = "2014",
doi = "10.1016/j.jtcvs.2013.10.070",
language = "English",
volume = "147",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Universal definition of perioperative bleeding in adult cardiac surgery

AU - Dyke, Cornelius

AU - Aronson, Solomon

AU - Dietrich, Wulf

AU - Hofmann, Axel

AU - Karkouti, Keyvan

AU - Levi, Marcel

AU - Murphy, Gavin J.

AU - Sellke, Frank W.

AU - Shore-Lesserson, Linda

AU - Von Heymann, Christian

AU - Ranucci, Marco

PY - 2014

Y1 - 2014

N2 - Objectives: Perioperative bleeding is common among patients undergoing cardiac surgery; however, the definition of perioperative bleeding is variable and lacks standardization. We propose a universal definition for perioperative bleeding (UDPB) in adult cardiac surgery in an attempt to precisely describe and quantify bleeding and to facilitate future investigation into this difficult clinical problem. Methods: The multidisciplinary International Initiative on Haemostasis Management in Cardiac Surgery identified a common definition of perioperative bleeding as an unmet need. The functionality and usefulness of the UDPB for clinical research was then tested using a large single-center, nonselected, cardiac surgical database. Results: A multistaged definition for perioperative bleeding was created based on easily measured clinical end points, including total blood loss from chest tubes within 12 hours, allogeneic blood products transfused, surgical reexploration including cardiac tamponade, delayed sternal closure, and the need for salvage treatment. Depending on these components, bleeding is graded as insignificant, mild, moderate, severe, or massive. When applied to an established cardiac surgery dataset, the UDPB provided insight into the incidence and outcome of bleeding after cardiac surgery. Conclusions: The proposed UDPB in adult cardiac surgery provides a precise classification of bleeding that is useful in everyday practice as well as in clinical research. Once fully validated, the UDPB may be useful as an institutional quality measure and serve as an important end point in future cardiac surgical research.

AB - Objectives: Perioperative bleeding is common among patients undergoing cardiac surgery; however, the definition of perioperative bleeding is variable and lacks standardization. We propose a universal definition for perioperative bleeding (UDPB) in adult cardiac surgery in an attempt to precisely describe and quantify bleeding and to facilitate future investigation into this difficult clinical problem. Methods: The multidisciplinary International Initiative on Haemostasis Management in Cardiac Surgery identified a common definition of perioperative bleeding as an unmet need. The functionality and usefulness of the UDPB for clinical research was then tested using a large single-center, nonselected, cardiac surgical database. Results: A multistaged definition for perioperative bleeding was created based on easily measured clinical end points, including total blood loss from chest tubes within 12 hours, allogeneic blood products transfused, surgical reexploration including cardiac tamponade, delayed sternal closure, and the need for salvage treatment. Depending on these components, bleeding is graded as insignificant, mild, moderate, severe, or massive. When applied to an established cardiac surgery dataset, the UDPB provided insight into the incidence and outcome of bleeding after cardiac surgery. Conclusions: The proposed UDPB in adult cardiac surgery provides a precise classification of bleeding that is useful in everyday practice as well as in clinical research. Once fully validated, the UDPB may be useful as an institutional quality measure and serve as an important end point in future cardiac surgical research.

UR - http://www.scopus.com/inward/record.url?scp=84899982955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899982955&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2013.10.070

DO - 10.1016/j.jtcvs.2013.10.070

M3 - Article

C2 - 24332097

AN - SCOPUS:84899982955

VL - 147

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 5

ER -