TY - JOUR
T1 - Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma
T2 - Implications for the origin and selection of the malignant cells
AU - Agathangelidis, Andreas
AU - Hadzidimitriou, Anastasia
AU - Rosenquist, Richard
AU - Stamatopoulos, Kostas
PY - 2011/11
Y1 - 2011/11
N2 - Immunogenetic analysis of mantle cell lymphoma (MCL) has offered important evidence helping to decipher the immune pathways leading to its development and also prompting a reappraisal of the views about its ontogeny. In particular, older and more recent studies have demonstrated that MCL is characterized by a highly distinctive immunoglobulin gene repertoire with remarkable predominance of the IGHV3-21 and IGHV4-34 genes; restricted associations of IGHV, IGHD and IGHJ genes, culminating in the creation of quasi-identical (" stereotyped" ) heavy complementarity-determining region 3 sequences in roughly 10% of cases; and, very precisely targeted and, probably, functionally driven somatic hypermutation, ranging from minimal (in most cases) to pronounced. Furthermore, comparison to other entities, in particular CLL, revealed that several of these immunogenetic features are " MCL-biased" On these grounds, an antigen-driven origin of MCL could be envisaged, at least for subsets of cases.
AB - Immunogenetic analysis of mantle cell lymphoma (MCL) has offered important evidence helping to decipher the immune pathways leading to its development and also prompting a reappraisal of the views about its ontogeny. In particular, older and more recent studies have demonstrated that MCL is characterized by a highly distinctive immunoglobulin gene repertoire with remarkable predominance of the IGHV3-21 and IGHV4-34 genes; restricted associations of IGHV, IGHD and IGHJ genes, culminating in the creation of quasi-identical (" stereotyped" ) heavy complementarity-determining region 3 sequences in roughly 10% of cases; and, very precisely targeted and, probably, functionally driven somatic hypermutation, ranging from minimal (in most cases) to pronounced. Furthermore, comparison to other entities, in particular CLL, revealed that several of these immunogenetic features are " MCL-biased" On these grounds, an antigen-driven origin of MCL could be envisaged, at least for subsets of cases.
KW - Antigen selection
KW - CDR3
KW - Immunoglobulin genes
KW - Mantle cell lymphoma
KW - Somatic hypermutation
UR - http://www.scopus.com/inward/record.url?scp=82555169707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82555169707&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2011.09.009
DO - 10.1016/j.semcancer.2011.09.009
M3 - Article
C2 - 21946621
AN - SCOPUS:82555169707
VL - 21
SP - 299
EP - 307
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
IS - 5
ER -