Unmet Needs in the Pathogenesis and Treatment of Vasculitides

Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani

Research output: Contribution to journalArticle

Abstract

Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria. The lack of an accepted definition of disease activity in large-vessel vasculitides presents a major challenge in creating useful and valid outcome tools for the assessment of disease course. Identification of predictors of flares can aid in optimizing therapeutic strategies, minimizing disease flares, and reducing treatment-related side effects. It is furthermore important to recognize and characterize the risk factor that might predict the manifestations associated with poor outcome and prognosis. Two RCTs have evidenced the efficacy of tocilizumab in addition to glucocorticoids (GCs) in the treatment of giant cell arteritis (GCA). However, the role of tocilizumab or other biological agents without GCs needs to be investigated. Recent observational studies have suggested that rituximab is also effective in patients with eosinophilic granulomatosis with polyangiitis and in antineutrophil cytoplasmic antibodies (ANCA)-negative patients with granulomatosis with polyangiitis and microscopic polyangiitis. Rituximab or anti-TNF alfa may represent a possible alternative therapy in case of refractory or difficult to treat polyarteritis nodosa (PAN) patients. The new International Criteria for Behçet’s Disease have shown a better sensitivity and a better accuracy compared to the older International Study Group on Behçet’s Disease criteria. The EULAR recommendations for the management of Behçet’s disease (BD) have been recently updated. However, the treatment of refractory disease is still a real challenge.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalClinical Reviews in Allergy and Immunology
DOIs
Publication statusAccepted/In press - Sep 11 2017

Keywords

  • ANCA-associated vasculitis
  • Behçet’s disease
  • Large-vessel vasculitis
  • Rituximab
  • Tocilizumab
  • Treatment
  • Unmet needs
  • Vasculitis

ASJC Scopus subject areas

  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Unmet Needs in the Pathogenesis and Treatment of Vasculitides'. Together they form a unique fingerprint.

  • Cite this

    Muratore, F., Pazzola, G., Soriano, A., Pipitone, N., Croci, S., Bonacini, M., Boiardi, L., & Salvarani, C. (Accepted/In press). Unmet Needs in the Pathogenesis and Treatment of Vasculitides. Clinical Reviews in Allergy and Immunology, 1-17. https://doi.org/10.1007/s12016-017-8643-2