Unoperated ovarian endometriomas and responsiveness to hyperstimulation

Laura Benaglia, Roberta Pasin, Edgardo Somigliana, Paolo Vercellini, Guido Ragni, Luigi Fedele

Research output: Contribution to journalArticlepeer-review


BACKGROUND: There is a growing consensus that ovarian reserve is reduced after surgical excision of ovarian endometriomas. However, it remains to be fully clarified whether this damage precedes or follows surgery. In order to further elucidate this aspect, we evaluated ovarian responsiveness to hyperstimulation in women selected for IVF with unilateral unoperated endometriomas. The main aim of this study was to compare the number of developing follicles in the affected ovary with that in the contralateral intact gonad as a control. Methods Patients selected for IVF who were diagnosed with one or more monolateral endometriomas (diameter 15 mm) on the day of hCG administration in the affected and intact ovaries. Results Among the 84 women selected, the median interquartile range (IQR) number of follicles ≥11 mm in the affected and intact ovaries was 5 (3-7) and 5 (3-8), respectively (P = 0.36). The median (IQR) number of co-dominant follicles in the affected and intact ovaries was 3 (2-4) and 3 (2-5), respectively (P = 0.48). The number of co-dominant follicles was lower in the affected ovary in 36 cases (43%, 95% confidence interval: 32-53%). We also failed to identify any statistically significant difference between the two ovaries when evaluating data according to the number of cysts, their dimension, the dose of gonadotrophins used or the number of oocytes retrieved. CONCLUSIONS In women selected for IVF, the presence of an endometrioma does not markedly affect responsiveness to hyperstimulation.

Original languageEnglish
Pages (from-to)1356-1361
Number of pages6
JournalHuman Reproduction
Issue number6
Publication statusPublished - Jun 2011


  • endometrioma
  • endometriosis
  • IVF
  • ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Rehabilitation
  • Reproductive Medicine


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