Unraveling framework of the ancestral Mediator complex in human diseases

Claudio Napoli, Marcella Sessa, Teresa Infante, Amelia Casamassimi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalBiochimie
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Mediator Complex
Multiprotein Complexes
Untranslated RNA
RNA Polymerase II
Transcription
Nervous System Diseases
Cardiovascular Diseases
Yeasts
Messenger RNA
Yeast
Machinery
Elongation
Neoplasms
Therapeutics

Keywords

  • Cancer
  • CVD
  • Mediator complex
  • Transcription regulation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Unraveling framework of the ancestral Mediator complex in human diseases. / Napoli, Claudio; Sessa, Marcella; Infante, Teresa; Casamassimi, Amelia.

In: Biochimie, Vol. 94, No. 3, 03.2012, p. 579-587.

Research output: Contribution to journalArticle

Napoli, Claudio ; Sessa, Marcella ; Infante, Teresa ; Casamassimi, Amelia. / Unraveling framework of the ancestral Mediator complex in human diseases. In: Biochimie. 2012 ; Vol. 94, No. 3. pp. 579-587.
@article{1e6a509a1cd44ce2be24bb7729a9ee7d,
title = "Unraveling framework of the ancestral Mediator complex in human diseases",
abstract = "Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders.",
keywords = "Cancer, CVD, Mediator complex, Transcription regulation",
author = "Claudio Napoli and Marcella Sessa and Teresa Infante and Amelia Casamassimi",
year = "2012",
month = "3",
doi = "10.1016/j.biochi.2011.09.016",
language = "English",
volume = "94",
pages = "579--587",
journal = "Biochimie",
issn = "0300-9084",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Unraveling framework of the ancestral Mediator complex in human diseases

AU - Napoli, Claudio

AU - Sessa, Marcella

AU - Infante, Teresa

AU - Casamassimi, Amelia

PY - 2012/3

Y1 - 2012/3

N2 - Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders.

AB - Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders.

KW - Cancer

KW - CVD

KW - Mediator complex

KW - Transcription regulation

UR - http://www.scopus.com/inward/record.url?scp=84857060369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857060369&partnerID=8YFLogxK

U2 - 10.1016/j.biochi.2011.09.016

DO - 10.1016/j.biochi.2011.09.016

M3 - Article

VL - 94

SP - 579

EP - 587

JO - Biochimie

JF - Biochimie

SN - 0300-9084

IS - 3

ER -