Unraveling framework of the ancestral Mediator complex in human diseases

Claudio Napoli, Marcella Sessa, Teresa Infante, Amelia Casamassimi

Research output: Contribution to journalArticle

Abstract

Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalBiochimie
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Cancer
  • CVD
  • Mediator complex
  • Transcription regulation

ASJC Scopus subject areas

  • Biochemistry

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