Unraveling the multiple roles of leptin in inflammation and autoimmunity

Antonio La Cava, Carlo Alviggi, Giuseppe Matarese

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune homeostasis. Leptin links nutritional status and proinflammatory T helper 1 immune responses, and the decrease in leptin plasma concentration during food deprivation leads to impaired immune function. This review focuses on the multiple roles of leptin in chronic inflammation and autoimmunity and suggests new possible therapeutic implications for leptin modulators.

Original languageEnglish
Pages (from-to)4-11
Number of pages8
JournalJournal of Molecular Medicine
Volume82
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Leptin
Autoimmunity
Inflammation
Food Deprivation
Thermogenesis
Hematopoiesis
Nutritional Status
Reproduction
Homeostasis
Hormones
Therapeutics

Keywords

  • Autoimmunity
  • Inflammation
  • Leptin
  • T cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Unraveling the multiple roles of leptin in inflammation and autoimmunity. / La Cava, Antonio; Alviggi, Carlo; Matarese, Giuseppe.

In: Journal of Molecular Medicine, Vol. 82, No. 1, 01.2004, p. 4-11.

Research output: Contribution to journalArticle

La Cava, Antonio ; Alviggi, Carlo ; Matarese, Giuseppe. / Unraveling the multiple roles of leptin in inflammation and autoimmunity. In: Journal of Molecular Medicine. 2004 ; Vol. 82, No. 1. pp. 4-11.
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