Unraveling the multiple roles of leptin in inflammation and autoimmunity

Antonio La Cava, Carlo Alviggi, Giuseppe Matarese

Research output: Contribution to journalArticlepeer-review


Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune homeostasis. Leptin links nutritional status and proinflammatory T helper 1 immune responses, and the decrease in leptin plasma concentration during food deprivation leads to impaired immune function. This review focuses on the multiple roles of leptin in chronic inflammation and autoimmunity and suggests new possible therapeutic implications for leptin modulators.

Original languageEnglish
Pages (from-to)4-11
Number of pages8
JournalJournal of Molecular Medicine
Issue number1
Publication statusPublished - Jan 2004


  • Autoimmunity
  • Inflammation
  • Leptin
  • T cells

ASJC Scopus subject areas

  • Medicine(all)


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